| Gene name: | E2F7 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90 |
| Experiment: | BrdU assay//Colony formation assay//Cell counting |
| Description: | Still, in marked contrast, cosuppression of E2F7 together with RB was sufficient to bypass senescence, as measured by various proliferation assays such as BrdU incorporation, colony formation, and cell counting. |
| Regulatory pathway: | P53 |
| R-AG-Pathway: | -- |
| Official symbol(s): | TP53 |
| Pathway experiment: | CHIP-Seq |
| Pathway description: | Interestingly, E2F7 has a p53-binding site in its promoter, and indeed, analysis of chromatin immunoprecipitation (ChIP)/next-generation sequencing (ChIP-seq) data from IMR90 cells under different growth conditions revealed a marked and specific binding of p53 to this site in senescence but not in growing conditions .p53 binds to the E2F7 promoter specifically during cellular senescence. |
Annotation:
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