| Gene name: | SIRT1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | ES |
| Experiment: | FISH |
| Description: | Repair by NHEJ, the prominent DSB repair pathway in G1 and post-mitotic cells, was also reduced in this assay system, but to a lesser extent.H2O2 treatment caused a significant increase in chromosomal aberrations specifically in SIRT1 deficient cells. The frequency of chromatid breaks was comparable between knock-down and control ES cells, but the number of chromosomal fusions, in particular dicentric chromosomes and Robertsonian translocations, was significantly higher in the absence of SIRT1 . |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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