| Gene name: | AGER |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Lung |
| Cell name: | -- |
| Experiment: | SA-β-gal activity assay//Knockdown//Immunofluorescence//Histological staining |
| Description: | The absence of RAGE was associated with an accumulation of fibrotic tissue (as evidenced by Masson's trichrome staining) and senescent lesions, as evidenced by β-Gal-staining . The accumulation of these senescent lesions was also observed in other tissues of RAGE?/? mice.When markers of senescence associated cellular properties were studied, an increase of IL-6 by ～50% and an almost 3-fold increase of γH2AX and 53BP1 was seen, while pATM increased by ～50%. This is consistent with DNA damage associated senescence and a senescence associated pro-inflammatory phenotype in cells and lungs of RAGE?/? mice , indicating an on-going persistent DNA damage signaling. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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