| Gene name: | BECN1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | U87 |
| Experiment: | SA-β-gal activity assay//Knockdown//Flow cytometry//PI staining//MTT assay |
| Description: | Beclin-1 knockdown was found to inhibit cell proliferation,apparently, due to induction of cell cycle arrest (in 61% to 84% of total cells) in G1 phase.Beclin-1 knockdown in U87 cells results in blue βgalactosidase staining, which is known to be associated with expression and pH-dependent activation of a lysosomal enzyme senescence-associated β-galactosidase (SA-β-gal), a commonly used biomarker for cellular senescence. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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