| Gene name: | ACACA |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Human primary Fibroblast |
| Experiment: | BrdU assay//SA-β-gal activity assay |
| Description: | The incorporation of [methyl-3H] thymidine into DNA, normalized to total cell protein, was significantly reduced,as was the percentage of cell nuclei that incorporated BrdU. Besides, a nearly three-fold increase in SA-β-Gal positive cells was observed after silencing of ACC1 gene expression. |
| Target gene: | P38MAPK |
| Official symbol(s): | P38MAPK |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | p38 MAPK phosphorylation was stimulated by ACC1 silencing, while the overall expression of the kinase was not affected . As such, the ratio between the phosphorylated enzyme and total enzyme was more than three-fold higher in ACC1 shRNA treated cells than in the control. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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