Aging Overview

Aging gene

Gene name: MYC
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: TRE293
Gene ID: 4609
Category: protein coding
Phenotype: Aging
Experimental category: HL
PMID: 22146591
Experiment: Western blot//SA-β-gal activity assay
Description: TRE293 cells treated with c-Myc shRNA demonstrated significant changes in senescence and induced the p53/p21CIP1 pathway.


Regulatory relationship

Target gene: BAG2
Official symbol(s): BAG2
R-AG-Target gene: Downregulation
Subcategory: Unclear
Target gene experiment: Western blot//BrdU assay//SA-β-gal activity assay
Target gene description: In cells that demonstrated high levels of BAG2 in response to SP1 over-expression, transfection of c-Myc was shown to abrogate the BAG2 mRNA levels in a concentrationdependent manner.

Regulatory pathway: P53-P21
R-AG-Pathway: Upregulation
Official symbol(s): TP53-CDKN1A
Pathway experiment: Western blot
Pathway description: TRE293 cells treated with c-Myc shRNA demonstrated significant changes in senescence and induced the p53/p21CIP1 pathway.


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



Pathway view

About risk SNP and eQTL

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