Aging Overview

Aging gene

Gene name: BTK
Aging type: Accelerate
Aging characteristic:
Tissue type: Brain
Cell name: --
Gene ID: 695
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 31736210
Experiment: SA-β-gal activity assay//Knockdown//qRT-PCR
Description: To test whether BTK inhibition could prevent the age-dependent buildup of senescent cells in the brain, we measured the expression of different markers of senescence in brains of control and ibrutinib-treated Zmpste24?/? mice.This was concomitant with a decrease in p53 and p16 levels, as expected. In line with this, mRNA levels of BTK (which is a transcriptional target of p53 (Althubiti et al., 2016)) and other markers of senescence were also decreased in the brain samples. p53 mRNA levels did not change significantly, which is compatible with the post-translational effects of BTK on p53 levels (Althubitiet al., 2016). The reduction in senescent cell accumulation in brains of treated mice was confirmed by a whole organ SA-β-gal staining.




Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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