| Gene name: | CDKN2A |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | CPC |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | Interestingly, SAβG staining showed decreased numbers of senescent cells in the experimental hCPCs infected with lentivirus expressing shRNA against p16INK4A. |
| Regulatory pathway: | NF-κB |
| R-AG-Pathway: | Upregulation |
| Official symbol(s): | NFKB1 |
| Pathway experiment: | Western blot//RT-PCR |
| Pathway description: | RT-PCR and Western Blot with cytokines and NFκB related genes was performed and showed upregulation in NFKB1, TBK1, RELA, IKBKB, and TICAM2. NFKB2 and HMOX1 showed 3~4-fold increased mRNA expression, while TLR3 showed almost 5.5-fold increased mRNA expression in the sh-p16INK4A infected aging hCPCs compared to the control hCPCs. |
Annotation:
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