Aging Overview

Aging gene

Gene name: KNDC1
Aging type: Accelerate
Aging characteristic:
Tissue type: Umbilical cord
Cell name: HUVEC
Gene ID: 85442
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 29568929
Experiment: SA-β-gal activity assay
Description: The number of positive SA-β-Gal staining observed in the HUVECs following the transfection of the KNDC1?adenovirus vector significantly increased when compared with that in the control group.


Regulatory relationship

Regulatory pathway: P53
R-AG-Pathway: Upregulation
Official symbol(s): TP53
Pathway experiment: Western blot
Pathway description: However, a significant increase in the expression of p-p53 was observed in HUVECs that overexpressed KNDC1 when compared with the NT-adenovirus-transfected control cells.


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



Pathway view

About risk SNP and eQTL

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