| Gene name: | UHRF1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | Liver |
| Cell name: | Hepatocyte |
| Gene ID: | 29128 |
| Category: | protein coding |
| Phenotype: | Hepatocellular carcinoma |
| Experimental category: | HL |
| PMID: | 24486181 |
| Experiment: | SA-β-gal activity assay//qRT-PCR//RNA-seq |
| Description: | However, senescence associated β-galactosidase (SA-β-gal) staining was detected throughout the liver of most UHRF1-GFP High 5 dpf larvae, but not other transgenic lines. Additionally, the DNA in control hepatocytes was evenly distributed throughout the uniformly sized nuclei compared to the large nuclei where DNA resembled senescence associated heterochromatic foci. RNAseq revealed some pro-proliferative genes(ccnd1 and myc) downregulated. |
| Target gene: | TP53//CDKN1A |
| Official symbol(s): | TP53//CDKN1A |
| R-AG-Target gene: | Upregulation//Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | RNA-seq//qPCR |
| Target gene description: | RNAseq and qPCR analysis show that tp53 and its target genes, especially cdkn1a, are significantly induced in the liver of 5 dpf UHRF1-GFP High larvae. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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