| Gene name: | SIRT1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | BJ |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | Accordingly transfection of specific siRNA oligos independently targeting SIRT1 and SIRT2 significantly decreased expression of SIRT1/2 and induced senescence as shown by increased SA-βgal activity in BJ fibroblasts. Induction of senescence is mediated by DNA damage as evidenced by formation of-H2A.X foci and activation of p53-p21CIP1 pathway. A slight increase in levels of p16INK4A was also detected. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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