| Gene name: | LINC00673 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | A549,IMR-90 |
| Experiment: | Knockdown//Flow cytometry//SA-β-Gal activity assay//Cell morphological analysis |
| Description: | LINC00673 knockdown caused a change of cellular morphology, namely increased cell size and adaptation of a flat cell morphology in both A549 lung cancer cells and IMR-9 normal lung fibroblast cells.The reduction of LINC00673 levels in A549 cells was accompanied by a prominent increase of cells in G0/G1-phases and a concomitant decrease of cells in S-phase .We confirmed a strong increase of SA-β-Gal positive A549 and IMR-9 cells 4 days after LINC00673 knockdown. |
| Regulatory pathway: | P53 |
| R-AG-Pathway: | -- |
| Official symbol(s): | TP53 |
| Pathway experiment: | SA-β-Gal activity assay |
| Pathway description: | SiPOOL-mediated depletion of p53 was sufficient to overcome senescence triggered by LINC00673 depletion in A549 cells. |
Annotation:
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