| Gene name: | SIRT6 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | NHAC-kn |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | Furthermore, the SA-β-Gal assay showed that the percentage of SA-β-Gal-positive cells was significantly higher in the SIRT6 siRNA group (24.3 ± 4.2 %) than in the control group (11.3 ± 3.0 %), indicating that the depletion of SIRT6 induced premature senescence. |
| Target gene: | γH2AX//TIFS//P16//P21 |
| Official symbol(s): | H2AX//TIFS//P16//P21 |
| R-AG-Target gene: | --//--//--//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Immunofluorescence microscopic analysis//Western blot |
| Target gene description: | Immunofluorescence microscopic analyses showed that γH2AX foci and TIFs were increased in the SIRT6-depleted chondrocytes than in controls.The p16 protein level was higher and p21 protein level was lower in the SIRT6-depleted chondrocytes than those in control chondrocytes. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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