Gene name: | ARID1A |
Aging type: | Accelerate |
Aging characteristic: |
Tissue type: | -- |
Cell name: | HPNE |
Gene ID: | 8289 |
Category: | protein coding |
Phenotype: | Pancreatic cancer |
Experimental category: | L |
PMID: | 28942143 |
Experiment: | SA-β-gal activity assay//Knockdown |
Description: | ARID1A knockdown had no effect on cell apoptosis as demonstrated by Annexin V/Propidium Iodide apoptosis assay, but accelerated cell cycle progression in HPNE/KRASG12D cells. Second, ARID1A knockdown significantly reduced the percentage of senescence-associated bgal staining-positive cells. Third, accelerated cell cycle progression and inhibited senescence were also observed in the stable HPNE/KRASG12D/shARID1A cells compared with HPNE/KRASG12D/shNC control cells. |
Target gene: | P16 |
Official symbol(s): | P16 |
R-AG-Target gene: | Upregulation |
Subcategory: | Unclear |
Target gene experiment: | Western blot |
Target gene description: | The results showed that restored ARID1A expression led to increased expression of p16, promotion of cell senescence. |
Regulatory pathway: | -- |
R-AG-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation:
Loading,please wait...