Aging Overview

Aging gene

Gene name: ARID1A
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: HPNE
Gene ID: 8289
Category: protein coding
Phenotype: Pancreatic cancer
Experimental category: L
PMID: 28942143
Experiment: SA-β-gal activity assay//Knockdown
Description: ARID1A knockdown had no effect on cell apoptosis as demonstrated by Annexin V/Propidium Iodide apoptosis assay, but accelerated cell cycle progression in HPNE/KRASG12D cells. Second, ARID1A knockdown significantly reduced the percentage of senescence-associated bgal staining-positive cells. Third, accelerated cell cycle progression and inhibited senescence were also observed in the stable HPNE/KRASG12D/shARID1A cells compared with HPNE/KRASG12D/shNC control cells.


Regulatory relationship

Target gene: P16
Official symbol(s): P16
R-AG-Target gene: Upregulation
Subcategory: Unclear
Target gene experiment: Western blot
Target gene description: The results showed that restored ARID1A expression led to increased expression of p16, promotion of cell senescence.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

Loading,please wait...