| Gene name: | RNF114 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MEF,IMR-90,MCF-7 |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | Intriguingly, we found that ZNF313 depletion triggers cellular senescence in various human cancer cells . Moreover, ZNF313 expression was substantially lower in senescent versus young cells and its level correlated inversely with the replicative senescence of mouse embryonic fibroblast (MEF) and human fetal lung fibroblast (IMR90). It was also observed that adriamycin-induced senescence of MCF7 cells is accompanied with ZNF313 reduction and that basal senescence is suppressed and stimulated by elevation and depletion of ZNF313, respectively . Similarly, adriamycin- or γ-IR-induced senescence of HCT116 cells was down- and upregulated by WT-ZNF313 and siZNF313, respectively. ZNF313 inhibited basal or adriamycin-induced senescence in the presence or absence of XAF1 expression. |
| Target gene: | P21 |
| Official symbol(s): | P21 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | ZNF313 depletion resulted in a marked increase in p21WAF1 protein stability. ZNF313 depletion attenuated p21WAF1 ubiquitination. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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