| Gene name: | NOX4 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | REF52,TIG-3 |
| Experiment: | SA-β-gal activity assay |
| Description: | Nox1- and Nox4-overexpressing cells ceased to proliferate and accumulated SA‐β‐gal during 6–7?days postinfection, whereas vector control displayed little or no senescence biomarker and growth inhibition. |
| Regulatory pathway: | P16//P38 MAPK |
| R-AG-Pathway: | Upregulation//Upregulation |
| Official symbol(s): | CDKN2A//MAKP14 |
| Pathway experiment: | Western blot |
| Pathway description: | Nox4 caused accumulation of p16Ink4a?in TIG‐3 cells.Moreover, a marked increase in the level of phosphorylated p38MAPK was detected in Nox1‐ or Nox4‐expressing cells. |
Annotation:
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