| Gene name: | NAT10 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HGPS |
| Gene ID: | 55226 |
| Category: | protein coding |
| Phenotype: | Hutchinson-Gilford progeria syndrome |
| Experimental category: | HL |
| PMID: | 29970603 |
| Experiment: | SA-β-gal activity assay |
| Description: | Similarly, although NAT10 depletion strongly decreased the proportion of HGPS cells positive for senescenceassociated -galactosidase, this was not the case when NUP153 or TNPO1 was codepleted with NAT10. |
| Regulatory pathway: | TNPO1 |
| R-AG-Pathway: | -- |
| Official symbol(s): | TNPO1 |
| Pathway experiment: | Knockdown//Microarray//Western blot |
| Pathway description: | We observed that 70% of the genes showing significantly increased or decreased expression upon NAT10 depletion alone in control fibroblasts were not modified anymore upon simultaneous depletion of TNPO1, despite similar NAT10 protein knockdown. |
Annotation:
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