Aging Overview

Aging gene

Gene name: SIRT6
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: U2OS
Gene ID: 51548
Category: protein coding
Phenotype: Aging
Experimental category: HL
PMID: 27043296
Experiment: SA-β-gal activity assay
Description: We detected significantly increased numbers of senescent U2OS cells (over ~20-fold higher than control cells) within a week of SIRT6 depletion by lentiviral shRNAs, and increased senescence was observed as early as 72 hours after transient transfection of SIRT6 siRNAs.


Regulatory relationship

Target gene: H3K18AC
Official symbol(s): H3K18AC
R-AG-Target gene: --
Subcategory: Unclear
Target gene experiment: Western blot
Target gene description: Upon extending this analysis to new peptides, we found that SIRT6 robustly deacetylated lysine K18 on histone H3 peptides (H3K18Ac).SIRT6 also promoted H3K18Ac deacetylation when over-expressed in cells, while the mutant SIRT6 H133Y protein did not.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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