| Gene name: | POLB |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MEF |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | In the absence of HU or other DNA damaging agents, we find robust SA-β-Gal staining in the Polbcells, a much greater senescence response due to loss of Polb than we had anticipated .In addition to significant increase in SA-β-gal positive cells induced by loss of Polb, p16 was also significantly upregulated in the Polbcells, further supporting that senescence is induced when Polb is absent. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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