| Gene name: | HSPA9 |
| Aging type: | Accelerate |
| Aging characteristic: | Others |
| Tissue type: | Human tumor tissue and normal tissue |
| Cell name: | U2OS,Human immortalized postcrisis cell,Fibroblast |
| Experiment: | Cell counting//Western blot |
| Description: | Noticeably, mortalin-overexpressing cells were significantly more sensitive to 5AZA-dC, and showed a stronger induction level of p16INK4A. |
| Regulatory pathway: | P53-P21 |
| R-AG-Pathway: | Activation |
| Official symbol(s): | TP53-CDKN1A |
| Pathway experiment: | Western blot |
| Pathway description: | 5AZA-dC-treated cells indeed showed upregulation of p53 and its downstream effector, p21WAF1, in addition to p16INK4a, and exhibited nuclear translocation of the p53 protein. Whereas only 10% 20% of control cells showed nuclear p53, 90% of the 5AZA-dC-treated cells showed strong p53 staining in the nucleus . |
Annotation:
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