Aging Overview

Aging gene

Gene name: SOD1
Aging type: Prevent
Aging characteristic: Others
Tissue type: --
Cell name: WI-38,WI38-SV40
Gene ID: 6647
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 12871978
Experiment: Cell morphological analysis//SA-β-gal activity assay
Description: In contrast,the SOD1 RNAi-transfected cells no longer divided.In addition the SOD1 RNAi morphology was aberrant and cells had an increased cell area and flattened appearance .WI38 SOD1 RNAi cells exhibited significantly stronger activity of senescence-associated β-galactosidase than the control cells.


Regulatory relationship

Target gene: P53
Official symbol(s): P53
R-AG-Target gene: --
Subcategory: Unclear
Target gene experiment: Immunostaining
Target gene description: In contrast to control cells, SOD1 RNAi-transfected cells displayed the p53 protein in the nucleus and at elevated expression levels.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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