| Gene name: | PML |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MEF |
| Experiment: | SA-β-gal activity assay//Western blot//Cell morphological analysis |
| Description: | The frequency of SA-β-gal+ cells was markedly lower in Ras-expressing PMLMEFs than in controls.Morphologically, they became flat and enlarged and were strongly positive for SA-β-gal. Although PML and Ras induced equivalent levels of p53 and p21CIP1, PML did not influence p16 expression. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Acetylation |
| Target gene experiment: | Western blot |
| Target gene description: | Expression of oncogenic Ras or PML induced a modest, yet reproducible, increase in acetylation of p53 at K382, but not K320 (data not shown). |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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