Gene name: | GNAO1 |
Aging type: | Accelerate |
Aging characteristic: |
Tissue type: | -- |
Cell name: | GY-7703,SMMC-7721 |
Gene ID: | 2775 |
Category: | protein coding |
Phenotype: | Hepatocellular carcinoma |
Experimental category: | L |
PMID: | 23984917 |
Experiment: | CCK-8 assay//Western blot//SA-β-gal activity assay//Knockdown |
Description: | In the 96 h observation, we found that after 72 h of transfection, the cell proliferation was comparably faster in cells transfected with siGNAO1-1 and siGNAO1-2, in which the protein expression of GNAO1 was remarkably inhibited, than that in cells transfected with NC(P < 0.05).In β-gal staining assay, after 72 h of transfection, a lower proportion of senescent cells was observed in the group transfected with GNAO1 siRNA compared with that in the group of NC and NTC, indicating that down-regulation of GNAO1 inhibitedthe senescence of HCC cells. |
Regulatory pathway: | -- |
R-AG-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation:
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