Aging Overview

Aging gene

Gene name: GNAO1
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: GY-7703,SMMC-7721
Gene ID: 2775
Category: protein coding
Phenotype: Hepatocellular carcinoma
Experimental category: L
PMID: 23984917
Experiment: CCK-8 assay//Western blot//SA-β-gal activity assay//Knockdown
Description: In the 96 h observation, we found that after 72 h of transfection, the cell proliferation was comparably faster in cells transfected with siGNAO1-1 and siGNAO1-2, in which the protein expression of GNAO1 was remarkably inhibited, than that in cells transfected with NC(P < 0.05).In β-gal staining assay, after 72 h of transfection, a lower proportion of senescent cells was observed in the group transfected with GNAO1 siRNA compared with that in the group of NC and NTC, indicating that down-regulation of GNAO1 inhibitedthe senescence of HCC cells.


Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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