| Gene name: | LMNA |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Jun-82 |
| Gene ID: | 4000 |
| Category: | protein coding |
| Phenotype: | Hutchinson-Gilford progeria syndrome |
| Experimental category: | L |
| PMID: | 17870066 |
| Experiment: | Cell counting//qRT-PCR |
| Description: | Interestingly,a fibroblast line overexpressing wild-type lamin A (82-6 +wt) also exhibited a diminished replicative lifespan,comparable to those expressing mutant forms of lamin A.Telomeres of fibroblasts overexpressing lamin A,either wildtype or mutant, exhibited accelerated rates of shortening as compared to the parental control.When the rates of the telomere loss were plotted against the labeling indices, however, fibroblasts overexpressing wt lamin A showed the fastest rate of telomere loss . |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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