| Gene name: | PPAR |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Great saphenous vein wall |
| Cell name: | -- |
| Gene ID: | 5465 |
| Category: | protein coding |
| Phenotype: | Chronic venous disorder |
| Experimental category: | HL |
| PMID: | 33645625 |
| Experiment: | RT-qPCR//Immunohistochemical staining |
| Description: | We studied the gene and protein expression of α, β/δ and γ PPAR isoforms in venous wall from CVeD patients and HV controls. We observed a significant decrease in PPAR-α gene expression by RT-qPCR in CVeD patients with respect to HV controls (HV=5.224 [3.659-8.039] RQ vs CVeD=4.632 [2.365-6.387] RQ, ***p=0.0004). We also studied PPAR-α protein expression by immunohistochemistry (IHC). We observed a significant decrease in the score, with a mean of 1.500 [0.500-2.750] in the HV group and 0.000 [0.500-2.750] in the CVeD group, **p=0, 0001. Furthermore, The percentage of positive samples was 100% (n=27) in the HV group and 74.286% (n=26) in the CVeD group. |
| Target gene: | PPAR-α//PPAR-β/δ//TFEB |
| Official symbol(s): | PPAR-α//PPAR-β/δ//TFEB |
| R-AG-Target gene: | Downregulation//Downregulation//Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Immunohistochemical staining//qPCR |
| Target gene description: | We observed a significant ?decrease in PPAR-α gene expression by RT-qPCR in ?CVeD patients with respect to HV controls.//The score for ?PPAR-β/δ was significantly lower for patients with ?CVeD.//Our results showed that the gene expression of ?TFEB was significantly decreased in CVeD patients ?compared with the HV group. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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