Aging Overview

Aging gene

Gene name: HEPACAM
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: MCF-7
Gene ID: 220296
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 18845560
Experiment: SA-β-gal activity assay//Cell morphological analysis
Description: About 54.2% ( P ?


Regulatory relationship

Regulatory pathway: P53-P21
R-AG-Pathway: Upregulation
Official symbol(s): TP53-CDKN1A
Pathway experiment: SA-β-gal activity assay//Western blot
Pathway description: Higher protein levels of p53, p21 and p27, but lower levels of cyclin B1 and cdc2, were detected in cells expressing wild-type hepaCAM when compared with cells expressing vector and hCAM-tailless.MCF7 cells expressing hepaCAM were either untransfected or transfected with either control or p53 siRNA, and the protein levels of p21 and p27 were evaluated. In comparison with either the untransfected cells or cells transfected with control siRNA, knockdown of p53 by p53 siRNA lowered the expression of p21 but did not significantly change p27, indicating that, in the presence of hepaCAM, the increase of p21 expression is p53 dependent. In addition, downregulation of p53 in cells expressing hepaCAM resulted in decreased β-galactosidase staining, reduced cell size and increased cell growth, suggesting that suppression of p53 alleviates senescence induced by hepaCAM.


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



Pathway view

About risk SNP and eQTL

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