| Gene name: | SIRT1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HUVEC |
| Gene ID: | 23411 |
| Category: | protein coding |
| Phenotype: | Atherosclerosis |
| Experimental category: | L |
| PMID: | 25040736 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | We observed that the adenovirus-mediated SIRT1 knockdown directly induced senescence in young HUVECs. Conversely, SIRT1 overexpression significantly decreased SA-β-gal activity in senescent HUVECs, suggesting that SIRT1 protects against endothelial replicative senescence. |
| Target gene: | PAI-1 |
| Official symbol(s): | SERPINE1 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Binding to promoter Acetylation |
| Target gene experiment: | Western blot//qRT-PCR//Knockdown |
| Target gene description: | PAI-1 expression was dramatically enhanced after SIRT1 knockdown at both the mRNA and protein levels in young HUVECs, while SIRT1 overexpression markedly inhibited PAI-1 expression at both the mRNA and protein levels in senescent HUVECs. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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