| Gene name: | MYC |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | Pancreas |
| Cell name: | -- |
| Experiment: | Immunohistochemistry//RT-qPCR |
| Description: | We confirmed that the expression of SASP factors in i4F;Arfnull pancreas was increased to similar levels as those observed in i4F pancreas upon OSKM activation. |
| Target gene: | INK4A//P21//P53//IL-6 |
| Official symbol(s): | INK4A//P21//P53//IL6 |
| R-AG-Target gene: | --//--//--//-- |
| Subcategory: | Unclear |
| Target gene experiment: | SA-β-gal activity assay//Immunohistochemistry |
| Target gene description: | In parallel to this, i4F;Ink4a-null pancreas presented limited senescence after OSKM activation, and little expression of senescence-associated genes like Arf, p53, and p21 as well as Il6 and other factors involved in the SASP, such as Tnf, Il1a, Il1b, Il1rn, Mmp3, and Pai1. We also observed an increased accumulation of reprogrammed (NANOG+) and senescent (SAβG+) cells in the pancreas of i4F;p21-null mice compared to i4F controls. In agreement, the levels of SASP factors, such as Il6, Tnf, and Pai1, presented the same tendency, that is, i4F |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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