Aging Overview

Aging gene

Gene name: PRC2
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: TIG-3
Gene ID: 3647044
Category: protein coding
Phenotype: Aging
Experimental category: HL
PMID: 17344414
Experiment: SA-β-gal activity assay//Western blot//qPCR//CHIP
Description: Therefore, to formally establish that a decreasing pool of the PRC2 complex directly leads to senescence and displacement of BMI1, we targeted the expression of EZH2 and SUZ12 by short hairpin interference.The loss of either protein results in the disruption of the PRC2 complex (Pasini et al. 2004b) and leads to the decrease of H3K27me3 and displacement of both BMI1 and CBX8 from the INK4A promoter. Significantly, cells depleted of EZH2 or SUZ12, similar to cells depleted of BMI1, activate INK4A transcription and become senescent .


Regulatory relationship

Target gene: INK4A
Official symbol(s): INK4A
R-AG-Target gene: --
Subcategory: Unclear
Target gene experiment: Western blot//SA-β-gal activity assay
Target gene description: We targeted the expression of EZH2 and SUZ12 by short hairpin interference. The loss of either protein results in the disruption of the PRC2 complex (Pasini et al. 2004b).cells depleted of EZH2 or SUZ12, similar to cells depleted of BMI1, activate INK4A transcription and become senescent.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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