Aging Overview

Aging gene

Gene name: DPP4
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: WI-38
Gene ID: 1803
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 28877934
Experiment: SA-β-gal activity assay//Western blot
Description: As shown, markers p16 and p21 were elevated while SIRT1 levels declined in cells overexpressing DPP4, supporting the notion that DPP4 promoted cell senescence. In addition, overexpression of DPP4 in WI-38 cells elevated SA-β-gal activity and decreased 3 H-thymidine incorporation.


Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

Loading,please wait...