| Sen_E_001 | lipopolysaccharide | γ-H2A.X//P16 | Upregulation//Upregulation | | Upregulation | Chemical compounds | DPSC | Human impacted third molar | Aging | Accelerate | | L | 24676500 |
| Sen_E_002 | Resveratrol | β-CATENIN | Downregulation | | Downregulation | Chemical compounds | MSC | Bone marrow | Aging | Prevent | | L | 26456654 |
| Sen_E_003 | Acrolein | WRN | Downregulation | | Activation | Chemical compounds | HFL-1 | -- | Aging | Accelerate | | L | 24747221 |
| Sen_E_004 | Ang II | TRF2 | Downregulation | | Upregulation//Upregulation | Chemical compounds | BVSMC | -- | Cerebrovascular aging | Accelerate | | L | 27364911 |
| Sen_E_005 | Morin | TNF-α//IL-1 β//IL-6 | Downregulation//Downregulation//Downregulation | | -- | Chemical compounds | Human interfollicular epidermal stem cell | Foreskin | Aging | Prevent | | L | 23952478 |
| Sen_E_006 | As2O3 | P53//P21 | Upregulation//Upregulation | | -- | Chemical compounds | U87,U251,SHG44,C6 | Glioma | Glioblastoma | Accelerate | | L | 26871293 |
| Sen_E_007 | Telomestatin | POT1//TRF2 | Downregulation//Downregulation | | -- | Chemical compounds | HT-1080 | -- | Fibrosarcoma | Accelerate | | L | 17050546 |
| Sen_E_008 | Tamoxifen | YPEL3 | Upregulation | | -- | Chemical compounds | MCF-7 | -- | Breast cancer | Accelerate | | L | 21671470 |
| Sen_E_009 | RTI | P53//P21 | Upregulation//Upregulation | | -- | Chemical compounds | MCAS,HEC-1 | -- | Gynaecological Cancer | Accelerate | | L | 10533489 |
| Sen_E_010 | E235 | ATF4 | Upregulation | | -- | Chemical compounds | HT-1080,B16F10 | -- | Cancer | Accelerate | | L | 23229510 |
| Sen_E_011 | AngII | TERT//UCP2//P-AKT//C-MYC//P53 | Upregulation//Upregulation//Upregulation//Upregulation//Upregulation | | -- | Chemical compounds | HUVEC | -- | Aging | Accelerate | | L | 25078983 |
| Sen_E_012 | Triptonide | TERT//C-MYC//P16//P21//DDIT3 | Downregulation//Downregulation//Upregulation//Upregulation//Upregulation | | Upregulation//Downregulation | Chemical compounds | U937,HL60 | -- | Acute leukemia | Accelerate | | L | 27908660 |
| Sen_E_013 | Resveratrol | TELOMERASE | Activation | | -- | Chemical compounds | EPC | -- | Aging | Prevent | | L | 18587418 |
| Sen_E_014 | Carbocysteine | SURVIVIN | Downregulation | | Upregulation | Chemical compounds | Endothelial cell | -- | Chronic obstructive pulmonary disease | Prevent | | L | 27237816 |
| Sen_E_015 | Cigarette smoke extract | SURVIVIN | Upregulation | | Downregulation | Other | Endothelial cell | -- | Chronic obstructive pulmonary disease | Accelerate | | L | 27237816 |
| Sen_E_016 | Catalpol | -- | -- | | -- | Chemical compounds | THP-1 | -- | Atherosclerosis | Prevent | | L | 30046372 |
| Sen_E_017 | G-quadruplex interActivate agent S2T1-6OTD | C-MYC//HTERT | Downregulation//Downregulation | | -- | Chemical compounds | D341,D425,Daoy ,BT-12,BT-16 | -- | Tumor | Accelerate | | L | 20053783 |
| Sen_E_018 | CRT0063465 | PGK1//DJ1 | --//-- | | -- | Chemical compounds | HCT116 | -- | Hypoglycemia | Prevent | | L | 31401411 |
| Sen_E_019 | Paclitaxel | PAI-1//ENOS//SIRT1 | Upregulation//Downregulation//Downregulation | | -- | Chemical compounds | HUVEC | -- | Aging | Accelerate | | L | 19520256 |
| Sen_E_020 | Sirolimus | PAI-1//ENOS//SIRT1 | Upregulation//Downregulation//Downregulation | | -- | Chemical compounds | HUVEC | -- | Aging | Accelerate | | L | 19520256 |
| Sen_E_021 | LG2055 | SKN-1 | Upregulation | | Activation | Chemical compounds | -- | Worm | Aging | Prevent | | L | 26710940 |
| Sen_E_022 | Vitamin D3 | SKN-1 | -- | | -- | Chemical compounds | -- | Worm | Aging | Prevent | | HL | 27783938 |
| Sen_E_023 | Calorie restriction | SIRT6 | Upregulation | | Downregulation | Other | -- | Kidney | Aging | Prevent | | L | 26940461 |
| Sen_E_024 | Carbamide peroxide | SIRT6 | Upregulation | | Downregulation | Chemical compounds | RPMI8226 | -- | Myeloma | Accelerate | | L | 30402853 |
| Sen_E_025 | PQQ | SIRT1//SIRT6 | Upregulation//Upregulation | | Activation | Chemical compounds | HDF | -- | Aging | Prevent | | L | 26126510 |
| Sen_E_026 | Everolimus | PAI-1//ENOS//SIRT1 | Upregulation//Downregulation//Downregulation | | -- | Chemical compounds | HUVEC | -- | Aging | Accelerate | | L | 19520256 |
| Sen_E_027 | Aspirin | PAI-1 | Downregulation | | -- | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 19520256 |
| Sen_E_028 | Metformin | MIR-200A | Upregulation | | -- | Chemical compounds | MEF | Embryo | Aging | Accelerate | | L | 22356767 |
| Sen_E_029 | PD-0332991 | FOXM1 | Downregulation | | -- | Chemical compounds | EC109,EC9706 | -- | Esophageal cancer | Accelerate | | L | 28444744 |
| Sen_E_030 | 5-AZA | -- | -- | | -- | Chemical compounds | ASC | Adipose | Aging | Prevent | | L | 27998022 |
| Sen_E_031 | Doxorubicin | SIRT1//SIRT3 | Downregulation//Downregulation | | Activation | Chemical compounds | BJ | -- | Aging | Accelerate | | L | 25924011 |
| Sen_E_032 | Resveratrol | SIRT1//SIRT2//P16 | Downregulation//Downregulation//Activation | | Activation | Chemical compounds | BJ | -- | Aging | Accelerate | | L | 25924011 |
| Sen_E_033 | Baker ethanol extract | SIRT1//PGC-1α | Upregulation//Upregulation | | Downregulation//Downregulation//Downregulation | Chemical compounds | Hs68 | -- | Aging | Prevent | | L | 28831286 |
| Sen_E_034 | HIV Tat | SIRT1//MIR-34A//MIR-138 | Downregulation//Upregulation//Upregulation | | Upregulation | Other | PT-ECFC | -- | Aging | Accelerate | | L | 28236278 |
| Sen_E_035 | Atorvastatin | SIRT1//ENOS | Upregulation//Activation | | -- | Chemical compounds | Endothelial cell | -- | Aging | Prevent | | L | 20705918 |
| Sen_E_036 | Regulatory T cells | α+β+HTERT | Upregulation | | -- | Other | CD4+CD25?T,CD8+T,B,NK | Blood | Aging | Accelerate | | L | 30025223 |
| Sen_E_037 | Lipodystrophy | ZMPSTE24 | Downregulation | | -- | Other | VSMC | -- | Aging | Accelerate | | L | 26724531 |
| Sen_E_038 | HIV protease inhibitors | ZMPSTE24 | Downregulation | | -- | Other | VSMC | -- | Aging | Accelerate | | L | 26724531 |
| Sen_E_039 | Estrogen | YPEL3 | Downregulation | | -- | Chemical compounds | MCF-7 | -- | Breast cancer | Prevent | | L | 21671470 |
| Sen_E_040 | Estrogen | WRN | Upregulation | | -- | Chemical compounds | A549 | -- | Werner syndrome | Prevent | | L | 20395656 |
| Sen_E_041 | Pravastatin | SIRT1//ENOS | Upregulation//Activation | | -- | Chemical compounds | Endothelial cell | -- | Aging | Prevent | | L | 20705918 |
| Sen_E_042 | Pitavastatin | SIRT1//ENOS | Upregulation//Activation | | -- | Chemical compounds | Endothelial cell | -- | Aging | Prevent | | L | 20705918 |
| Sen_E_043 | Ionizing radiation | SIRT1 | Downregulation | | --//-- | Other | Rabbit Articular Chondrocyte | -- | Aging | Accelerate | | L | 19887452 |
| Sen_E_044 | Sirtinol | SIRT1 | Downregulation | | -- | Chemical compounds | MCF-7,H1299 | -- | Cancer | Accelerate | | L | 16170353 |
| Sen_E_045 | Trimethylamine-N-oxide | SIRT1 | Downregulation | | Activation | Chemical compounds | -- | Aorta | Cardiovascular disease | Accelerate | | L | 29325896 |
| Sen_E_046 | Bood flow | SIRT1 | -- | | -- | Other | HUVEC | Aorta | Atherosclerosis | Accelerate | | L | 24651677 |
| Sen_E_047 | Glucocorticoid | SIRT1 | Downregulation | | Activation | Chemical compounds | Tenocyte | -- | Aging | Accelerate | | L | 23727633 |
| Sen_E_048 | Inauhzin | SIRT1 | Downregulation | | Upregulation | Chemical compounds | H460 | -- | Lung cancer | Accelerate | | L | 22331558 |
| Sen_E_049 | Vitamin D | SIRT1 | Upregulation | | Downregulation | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 26335302 |
| Sen_E_050 | Glucose Restriction | SIRT1 | Upregulation | | Downregulation//Activation | Other | Fibroblast | -- | Aging | Prevent | | L | 21390332 |
| Sen_E_051 | Amyloid beta oligomer | VEGFR-1//RAC1 | Upregulation//Downregulation | | -- | Other | HBMEC | -- | Aging | Accelerate | | L | 31513781 |
| Sen_E_052 | Resveratrol | UH2B | Downregulation | | -- | Chemical compounds | U87 MG,U-118 MG | -- | Glioma | Accelerate | | L | 21481687 |
| Sen_E_053 | 4-hydroxynonenal | TXNIP//PPARD | Upregulation//Activation | | -- | Chemical compounds | VEC | -- | Aging | Accelerate | | L | 25754218 |
| Sen_E_054 | Sulforaphane | TXNIP//HK2 | Upregulation//Downregulation | | -- | Chemical compounds | Chondrocyte | -- | Aging | Prevent | | HL | 30595796 |
| Sen_E_055 | Harmine | TWIST1//E3A | Downregulation//Downregulation | | -- | Chemical compounds | A549,H460,H358 | -- | Lung cancer | Accelerate | | L | 28851812 |
| Sen_E_056 | BTM-0512 | SIRT1 | Activation | | -- | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 20132235 |
| Sen_E_057 | Bradykinin | RB | Downregulation | | --//-- | Other | EPC | -- | Diabetes | Prevent | | HL | 26360782 |
| Sen_E_058 | Temsirolimus | PROGERIN | Downregulation | | Downregulation | Chemical compounds | Fibroblast | -- | Hutchinson-Gilford progeria syndrome | Prevent | | L | 28033363 |
| Sen_E_059 | ZnPyr | P53//P38//NAC | --//--//-- | | -- | Chemical compounds | Dermal Fibroblast | Skin | Aging | Accelerate | | L | 21557991 |
| Sen_E_060 | G-quadruplex ligand 12459 | P53//CHK1 | Upregulation//Activation | | Activation | Chemical compounds | A549 | -- | Aging | Accelerate | | L | 23396447 |
| Sen_E_061 | HU | TRP53 | Upregulation | | -- | Chemical compounds | MEF | Embryo | Aging | Accelerate | | HL | 26765334 |
| Sen_E_062 | HCV infection | TRF2 | Downregulation | | -- | Other | CD4+T | Blood | Aging | Accelerate | | L | 30185784 |
| Sen_E_063 | Cigarette smoke | TPP1//SIRT1 | Downregulation//-- | | -- | Other | HFL-1 | Lung | Chronic obstructive pulmonary disease | Accelerate | | L | 27559927 |
| Sen_E_064 | γ-irradiation | TP73 | Activation | | -- | Other | HCT116 | -- | Aging | Accelerate | | L | 29511339 |
| Sen_E_065 | Areca nut alkaloids | TGF-β//MMP2 | Upregulation//Upregulation | | -- | Chemical compounds | NHOF-1,NHOF-5 | -- | Oral submucous fibrosis | Accelerate | | L | 26414019 |
| Sen_E_066 | Metformin | P53 | -- | | Activation | Chemical compounds | HepG2 | -- | Hepatocellular carcinoma | Accelerate | | L | 23982736 |
| Sen_E_067 | BI+PAC | P38 | Downregulation | | Downregulation | Chemical compounds | MCF-7,T47D | -- | Breast cancer | Prevent | | L | 26349973 |
| Sen_E_068 | Matrine | P27 | Upregulation | | Downregulation | Chemical compounds | GBM | -- | Aging | Accelerate | | HL | 30079478 |
| Sen_E_069 | TMZ | P21//NF-κB | --//-- | | -- | Chemical compounds | LN-229-MGMT,U87,LN-229 | -- | Glioblastoma | Accelerate | | L | 30361254 |
| Sen_E_070 | The BET bromodomain inhibitor JQ1 | P21 | Upregulation | | Activation | Other | SW 13 53 | -- | Chondrosarcoma | Accelerate | | L | 28059436 |
| Sen_E_071 | TSY-1 | TERT | Downregulation | | -- | Chemical compounds | HL60,PBMV,HSC | -- | Aging | Accelerate | | HL | 28002788 |
| Sen_E_072 | GAPDH | TERC | -- | | -- | Chemical compounds | MCF-7 | -- | Breast cancer | Accelerate | | L | 22847419 |
| Sen_E_073 | F14512 | SURVIVIN | Upregulation | | -- | Chemical compounds | P388 | -- | Cancer | Accelerate | | L | 22127645 |
| Sen_E_074 | Losartan | STAT1 | Downregulation | | -- | Chemical compounds | Human mesangial cell | -- | Aging | Prevent | | L | 22217266 |
| Sen_E_075 | AngⅡ | STAT1 | Activation | | -- | Chemical compounds | Human mesangial cell | -- | Aging | Accelerate | | L | 22217266 |
| Sen_E_076 | Low-power laser irradiation | P21 | Downregulation | | Activation | Other | NIH-3T3 | -- | Aging | Prevent | | L | 23804320 |
| Sen_E_077 | Palbociclib | P21 | Upregulation | | Activation | Chemical compounds | MPM | -- | Malignant pleural mesothelioma | Accelerate | | L | 28704762 |
| Sen_E_078 | PM2.5 | P16INK5A//TET//DNMT | Upregulation//Upregulation//Downregulation | | Activation | Other | Keratinocyte | -- | Aging | Accelerate | | HL | 31551408 |
| Sen_E_079 | Angelica sinensis Polysaccharides | P16//P21//CYCLIN E//CDK4 | Upregulation//Upregulation//Downregulation//Downregulation | | Upregulation//Upregulation | Chemical compounds | CD34+CD38- | -- | Acute Leukemia | Accelerate | | L | 24377566 |
| Sen_E_080 | IL-6/sIL-6R | P15INK4B (CDKN2B)//STAT3//IGFBP5 | Upregulation//--//-- | | -- | Chemical compounds | TIG-3 | -- | Aging | Accelerate | | L | 22374671 |
| Sen_E_081 | AngII | STAT1 | Activation | | -- | Chemical compounds | HMC | -- | Aging | Accelerate | | L | 22193460 |
| Sen_E_082 | H2O2 | STAT1 | Activation | | -- | Chemical compounds | HMC | -- | Aging | Accelerate | | L | 22193460 |
| Sen_E_083 | Sodium butyrate | SRSF2 | Upregulation | | -- | Chemical compounds | H1299 | -- | Lung cancer | Accelerate | | L | 21555914 |
| Sen_E_084 | Mithramycin | SP1//P53 | Downregulation// | | -- | Chemical compounds | MES1,MES7 | -- | Malignant pleural mesothelioma | Accelerate | | HL | 26459178 |
| Sen_E_085 | Lactate | SNAIL//P16 | Upregulation//Downregulation | | -- | Chemical compounds | B2B | -- | Lung cancer | Prevent | | HL | 29482580 |
| Sen_E_086 | Antcin M | NRF2 | Activation | | Upregulation | Chemical compounds | HNDF,CCD966SK | -- | Aging | Prevent | | L | 27542238 |
| Sen_E_087 | Paeonol | NRF2 | Upregulation | | Upregulation//Downregulation//Downregulation | Chemical compounds | MRC-5 | -- | Aging | Prevent | | L | 28801702 |
| Sen_E_088 | Purple sweet potato color | NLRP3 INFLAMMASOMES | Downregulation | | Downregulation | Other | Endothelial cell | -- | Cardiovascular disease | Prevent | | L | 30585631 |
| Sen_E_089 | DNA damage | MYBBP1A | Downregulation | | -- | Other | FaDu | -- | Aging | Accelerate | | HL | 25543088 |
| Sen_E_090 | Calorie restricted | MMP2 | -- | | Upregulation//Downregulation | Other | Fibroblast | -- | Aging | Prevent | | L | 25855056 |
| Sen_E_091 | Butylidenephthalide | SKP2 | Downregulation | | -- | Chemical compounds | GBM8401 | -- | Brain tumor | Accelerate | | L | 24464249 |
| Sen_E_092 | Glucose | SIRT3 | Inhibition | | -- | Chemical compounds | WI-38 | -- | Aging | Accelerate | | L | 23494737 |
| Sen_E_093 | Salidroside | SIRT3 | Upregulation | | -- | Chemical compounds | Aortic Endothelial cell,Smooth muscle cell,HUVEC | -- | Aging | Prevent | | L | 29289557 |
| Sen_E_094 | HRW | SIRT3 | Upregulation | | -- | Chemical compounds | Retinal cell | -- | Aging | Prevent | | L | 30735837 |
| Sen_E_095 | Ubiquinol-10 | SIRT1//PGC-1A//SIRT3 | Upregulation//Upregulation//Upregulation | | -- | Chemical compounds | HepG2 | -- | Aging | Prevent | | L | 24124769 |
| Sen_E_096 | MALAT1 | MMP1 | Downregulation | | -- | Other | Fibroblast | -- | Aging | Prevent | | L | 28487970 |
| Sen_E_097 | Low frequency magnetic fields | MIR-34A//P53 | Upregulation//Upregulation | | -- | Other | A549,LLC | -- | Lung cancer | Accelerate | | L | 28389657 |
| Sen_E_098 | Kallistatin | MIR-21 | Downregulation | | -- | Chemical compounds | EPC | -- | Aging | Prevent | | L | 28544111 |
| Sen_E_099 | High Glucose | MIR-126 | Downregulation | | --//-- | Other | HGMC | -- | Diabetes kidney disease | Accelerate | | L | 30341510 |
| Sen_E_100 | Hypoxia | MIF | Upregulation | | Activation | Other | HMSC | Bone marrow | Aging | Prevent | | L | 24274936 |
| Sen_E_101 | Trans-Cinnamaldehyde | SIRT1//P53//P21 | Upregulation//Downregulation//Downregulation | | -- | Chemical compounds | ADSC | -- | Aging | Prevent | | HL | 25654692 |
| Sen_E_102 | 2-O-α-glucopyranosyl-L-ascorbic acid | SIRT1//P53//P21 | --//Downregulation//Downregulation | | -- | Chemical compounds | NHDF | -- | Aging | Prevent | | L | 22119379 |
| Sen_E_103 | N-acetylcysteine | SIRT1//P53 | Upregulation//Downregulation | | -- | Chemical compounds | γδ Treg cell | -- | Chronic kidney disease | Prevent | | L | 30447351 |
| Sen_E_104 | Curcumin | SIRT1//P21 | Activation//Downregulation | | -- | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 26235577 |
| Sen_E_105 | Red wine extract | SIRT1//ENOS//COX-2 | Activation//Upregulation//Upregulation | | -- | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 22563892 |
| Sen_E_106 | FL118 | MDMX | Downregulation | | Activation | Chemical compounds | HCT-8 | -- | Colorectal cancer | Accelerate | | L | 25512388 |
| Sen_E_107 | PD-0332991 | MDM2//P53//P21/WAF1 | Downregulation//Downregulation//Upregulation | | Activation | Chemical compounds | MEF | -- | Melanoma | Accelerate | | HL | 28039358 |
| Sen_E_108 | 20(s)-Rg3 | MDM2 | Downregulation | | Activation | Chemical compounds | NOZ,GBC-SD | -- | Gallbladder cancer | Accelerate | | L | 26309394 |
| Sen_E_109 | UVB irradiation | MALAT1//MMP1 | Upregulation//Upregulation | | Activation | Other | Fibroblast | -- | Aging | Accelerate | | L | 28487970 |
| Sen_E_110 | CAPERα-TBX3 repressor complex | LNCRNA UCA1 | Downregulation | | Downregulation | Other | HEK293,Primary HFF,MEF | -- | Aging | Prevent | | HL | 24876127 |
| Sen_E_111 | Simvastatin | SIRT1 | Upregulation | | -- | Chemical compounds | Endothelial cell | -- | Cardiovascular disease | Prevent | | L | 22964779 |
| Sen_E_112 | Nicotinamide | SIRT1 | Downregulation | | -- | Chemical compounds | HUVEC | -- | Aging | Accelerate | | L | 24729176 |
| Sen_E_113 | Selaginellin | SIRT1 | Upregulation | | -- | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 20224429 |
| Sen_E_114 | OX-LDL | SIRT1 | Downregulation | | -- | Chemical compounds | Endothelial cell | -- | Cardiovascular disease | Accelerate | | L | 22964779 |
| Sen_E_115 | NaHS | SIRT1 | Upregulation | | -- | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 24729176 |
| Sen_E_116 | Kallistatin | LET-7G | Upregulation | | -- | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 29992759 |
| Sen_E_117 | Hyperphosphatemia | INTEGRIN LINKED KINASE (ILK) | Upregulation | | Activation | Other | HASMC | Aorta | Aging | Accelerate | | L | 26467393 |
| Sen_E_118 | Rapamycin | IL1A | Downregulation | | --//Downregulation | Chemical compounds | Fibroblast | -- | Aging | Prevent | | L | 26147250 |
| Sen_E_119 | H2O2 | IGFBP3 | Downregulation | | Activation//-- | Chemical compounds | IMR-90 | -- | Aging | Accelerate | | L | 29579543 |
| Sen_E_120 | Resveratrol | HO-1//NQO-1 | Upregulation//Upregulation | | Upregulation//Upregulation//Upregulation | Chemical compounds | -- | Kidney | Renal?injury | Prevent | | L | 29326403 |
| Sen_E_121 | EtOH | SIRT1 | Downregulation | | -- | Chemical compounds | BM-MSC | -- | Osteoporosis | Accelerate | | L | 28339869 |
| Sen_E_122 | Trans-Resveratrol | SIRT1 | Upregulation | | -- | Chemical compounds | -- | Aorta | Diabetes | Prevent | | L | 23859249 |
| Sen_E_123 | Ginsenoside Rb1 | SIRT1 | Upregulation | | -- | Chemical compounds | HUVEC | Umbilical cord,Aorta | Cardiovascular disease | Prevent | | L | 31658172 |
| Sen_E_124 | 17β-estradiol | SIRT1 | Upregulation | | -- | Chemical compounds | HUVEC | Aorta | Cardiovascular disease | Prevent | | L | 31105126 |
| Sen_E_125 | SERM | SIRT1 | Upregulation | | -- | Chemical compounds | -- | Aorta | Cardiovascular disease | Prevent | | L | 31105126 |
| Sen_E_126 | 5-MTP | FOXO3A | Upregulation | | -- | Chemical compounds | BM-MSC | -- | Aging | Prevent | | L | 28894133 |
| Sen_E_127 | zofenoprilat | FGF-2//TERT | Activation//Upregulation | | Activation//Activation | Chemical compounds | CVEC,FGF-2(-/-) | -- | Aging | Prevent | | L | 19959747 |
| Sen_E_128 | Lidamycin | EZH2 | Downregulation | | Upregulation | Chemical compounds | Colon cancer cell | Colon | Colorectal cancer | Accelerate | | HL | 27882937 |
| Sen_E_129 | Low doses of ionizing radiation | ERK//MAPK | Activation | | -- | Other | MCF-7 | -- | Aging | Prevent | | L | 20428768 |
| Sen_E_130 | 2,3,5,40-tetrahydroxystilbene-2-O-b-D-glucoside | ENOS//P53 | Upregulation//Downregulation | | Upregulation | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 22981429 |
| Sen_E_131 | Testosterone | SIRT1 | Upregulation | | -- | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 22238626 |
| Sen_E_132 | X-radiation | SIRT1 | Downregulation | | -- | Other | BJ,MRC-5 | -- | Aging | Accelerate | | L | 25635860 |
| Sen_E_133 | OVX surgery | SIRT1 | Downregulation | | -- | Other | -- | Aorta | Menopause | Accelerate | | L | 31105126 |
| Sen_E_134 | Resveratrol | SIRT | Upregulation | | -- | Chemical compounds | PT-ECFC | -- | Preterm | Prevent | | L | 24518759 |
| Sen_E_135 | Glucose | SIRT | Downregulation | | -- | Chemical compounds | HREC | -- | Diabetes | Accelerate | | HL | 32026628 |
| Sen_E_136 | H2O2 | DUSP | Upregulation | | Downregulation | Chemical compounds | RPMI8226 | -- | Myeloma | Accelerate | | L | 30280787 |
| Sen_E_137 | Baicalin | DEPP | Upregulation | | Activation//Activation | Chemical compounds | HCT116,SW480 | -- | Colorectal cancer | Accelerate | | HL | 29440765 |
| Sen_E_138 | BAPTA | DDR | Downregulation | | Downregulation | Chemical compounds | HMESC | Blood | Aging | Prevent | | L | 27941214 |
| Sen_E_139 | SRM1649b | CYP1A1//MMP1 | Upregulation//Upregulation | | Activation | Chemical compounds | HaCaT,NHDF | -- | Aging | Accelerate | | L | 28526404 |
| Sen_E_140 | Betaine | COX-2 | Downregulation | | Downregulation//--//-- | Chemical compounds | YPEN-1 | -- | Aging | Prevent | | L | 16282556 |
| Sen_E_141 | Melatonin | RORα | Activation | | -- | Chemical compounds | HUVEC | Umbilical cord | Systemic lupus erythematosus | Prevent | | L | 32172204 |
| Sen_E_142 | Mussel oligopeptides | PRX1//NAMPT//SIRT1 | Upregulation//Upregulation//Upregulation | | -- | Other | MRC-5 | -- | Aging | Prevent | | L | 24238886 |
| Sen_E_143 | Melatonin | PRPC | Upregulation | | -- | Chemical compounds | CKD-mMSC | -- | Chronic kidney disease | Prevent | | L | 30372554 |
| Sen_E_144 | Azelaic acid | PPARγ | Activation | | -- | Chemical compounds | HDF | Foreskin | Aging | Prevent | | L | 23278893 |
| Sen_E_145 | PUVA | PPARγ | Downregulation | | -- | Other | HDF | Foreskin | Aging | Accelerate | | L | 23278893 |
| Sen_E_146 | Coumestrol | CKII | Downregulation | | Activation | Chemical compounds | MCF-7,HCT116 | -- | Aging | Accelerate | | L | 23768371 |
| Sen_E_147 | Tamoxifen | CK2 | Downregulation | | Upregulation | Chemical compounds | MCF-7,HCT116 | -- | Breast cancer | Accelerate | | L | 24361399 |
| Sen_E_148 | H2O2 | CAVEOLIN-1//P38MAPK//CII | Upregulation//--//Downregulation | | -- | Chemical compounds | Chondrocyte | -- | Osteoarthritis | Accelerate | | L | 16508959 |
| Sen_E_149 | Adriamycin | BMP4 | Upregulation | | Activation | Chemical compounds | A549,NCI-H460 | -- | Lung cancer | Accelerate | | L | 19269967 |
| Sen_E_150 | IRGs | AURKA//AURKB | Downregulation//Downregulation | | Upregulation | Other | IMR-90 | -- | Aging | Accelerate | | L | 26133385 |
| Sen_E_151 | T-oligo | POT1//TRF2 | Downregulation//Downregulation | | -- | Chemical compounds | LoVo | -- | Colorectal cancer | Accelerate | | L | 24632202 |
| Sen_E_152 | Gamma irradiation | PML | Upregulation | | -- | Other | MSC,Fibroblast | -- | Aging | Accelerate | | L | 26934440 |
| Sen_E_153 | GSK461364 | PLK1 | Downregulation | | -- | Chemical compounds | U2OS,MG-63,SJSA | -- | Osteosarcoma | Accelerate | | HL | 26794530 |
| Sen_E_154 | 12-O-tetradecanoylphorbol-13-acetate | PKCα//PERK1/2 | Downregulation//-- | | -- | Chemical compounds | HDF | -- | Aging | Prevent | | HL | 26912086 |
| Sen_E_155 | Glucagon‐like peptide 1 | PKA//ERK1/2//PI3K//NOS | Downregulation//Downregulation//Downregulation//Downregulation | | -- | Chemical compounds | EA.hy926 | -- | Aging | Prevent | | L | 28127745 |
| Sen_E_156 | ABT-737 | AMT | Activation | | Activation | Chemical compounds | PV-10,22RV1 | -- | Prostate cancer | Accelerate | | HL | 21084274 |
| Sen_E_157 | Icariin | AKT//ERK//ENOS | --//--//-- | | -- | Chemical compounds | HUVEC | Coronary artery | Aging | Prevent | | L | 23336586 |
| Sen_E_158 | HIV | -- | -- | | Downregulation | Other | HIVBaL | -- | Aging | Accelerate | | L | 28612507 |
| Sen_E_159 | Drug abuse | -- | -- | | Downregulation | Other | HFA | -- | Aging | Accelerate | | L | 28612507 |
| Sen_E_160 | Norcantharidin | -- | -- | | Downregulation | Chemical compounds | A549 | Lung | Lung cancer | Accelerate | | L | 27903989 |
| Sen_E_161 | TCDD | -- | -- | | Upregulation | Chemical compounds | Astrocyte | Brain | Aging | Accelerate | | L | 25382668 |
| Sen_E_162 | Aβ1-42 oligomers | -- | -- | | Upregulation//Upregulation | Chemical compounds | HBMEC | -- | Alzheimer's disease | Accelerate | | L | 30576228 |
| Sen_E_163 | 1,25(OH)2D3 | -- | -- | | -- | Chemical compounds | BM-MSC | -- | Osteoporosis | Prevent | | L | 31880094 |
| Sen_E_164 | Tumor-derived γδTreg cells | -- | -- | | -- | Other | γδ Treg cell | -- | Aging | Accelerate | | L | 23355732 |
| Sen_E_165 | Ultraviolet radiation | -- | -- | | -- | Other | HDF | -- | Aging | Accelerate | | HL | 30118525 |
| Sen_E_166 | Chitosan | -- | -- | | Downregulation | Chemical compounds | Fibroblast | Foreskin | Aging | Prevent | | L | 29081244 |
| Sen_E_167 | MHY2233 | -- | -- | | Upregulation | Chemical compounds | EPC | -- | Aging | Prevent | | L | 31223423 |
| Sen_E_168 | Atraric acid | -- | -- | | --//Activation | Chemical compounds | LNCaP | -- | Aging | Accelerate | | L | 25203674 |
| Sen_E_169 | Sjp40 | -- | -- | | -- | Chemical compounds | LX-2 | -- | Aging | Accelerate | | HL | 28325896 |
| Sen_E_170 | Melatonin | -- | -- | | -- | Chemical compounds | -- | Aorta | Aging | Prevent | | L | 22109832 |
| Sen_E_171 | Montelukast | -- | -- | | -- | Chemical compounds | Chondrocyte | -- | Osteoarthritis | Prevent | | L | 29331588 |
| Sen_E_172 | High glucose | -- | -- | | -- | Other | HUVEC | -- | Aging | Accelerate | | L | 26629991 |
| Sen_E_173 | Genistein | -- | -- | | Activation | Chemical compounds | HUVEC | Umbilical cord | Aging | Prevent | | L | 30443855 |
| Sen_E_174 | Aspirin | -- | -- | | -- | Chemical compounds | SW620,HCT116 | -- | Colorectal cancer | Accelerate | | L | 26219912 |
| Sen_E_175 | Ergothioneine | -- | -- | | Upregulation//Upregulation//Downregulation | Chemical compounds | Endothelial cell | -- | Type 2 diabetes mellitus | Prevent | | L | 27101740 |
| Sen_E_176 | Metformin | -- | -- | | Upregulation | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 26629991 |
| Sen_E_177 | Resveratrol | -- | -- | | Upregulation | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 26629991 |
| Sen_E_178 | Melatonin | -- | -- | | Upregulation | Chemical compounds | SH-SY5Y | -- | Aging | Prevent | | L | 28295567 |
| Sen_E_179 | Donepezil | -- | -- | | Activation | Chemical compounds | HUVEC | -- | Alzheimer’s disease | Prevent | | L | 26194321 |
| Sen_E_180 | Melatonin | -- | -- | | Upregulation | Chemical compounds | BM-MSC | -- | Aging | Prevent | | L | 25975679 |
| Sen_E_181 | Hydrogen sulfide | -- | -- | | Activation | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 23588928 |
| Sen_E_182 | CSE | -- | -- | | Activation | Other | 16HBE | -- | Aging | Accelerate | | L | 27555762 |
| Sen_E_183 | Cardiac glycoside | -- | -- | | -- | Chemical compounds | HeLa | -- | Aging | Accelerate | | L | 30369081 |
| Sen_E_184 | Arctigenin | -- | -- | | Downregulation | Chemical compounds | GBC | Cholecyst | Gallbladder cancer | Accelerate | | L | 28459363 |
| Sen_E_185 | CSE | -- | -- | | -- | Other | HBEC | -- | Aging | Accelerate | | L | 25714760 |
| Sen_E_186 | EGCG | -- | -- | | Downregulation | Chemical compounds | 3T3-L0 | -- | Aging | Prevent | | L | 30456590 |
| Sen_E_187 | High glucose | -- | -- | | Activation | Other | ARPE?19 | -- | Aging | Accelerate | | L | 30339883 |
| Sen_E_188 | Leptin/NAP-2 | -- | -- | | Activation | Chemical compounds | MSC | -- | Aging | Accelerate | | HL | 25989537 |
| Sen_E_189 | mTORC1 | -- | -- | | Activation | Chemical compounds | BJ-T | -- | Aging | Prevent | | L | 21909130 |
| Sen_E_190 | 17β-Estradiol | -- | -- | | Activation | Chemical compounds | EPC | -- | Aging | Prevent | | L | 16093915 |
| Sen_E_191 | High glucose | -- | -- | | --//Activation//-- | Other | EPC | Blood | Type 2 diabetes mellitus | Accelerate | | L | 28786152 |
| Sen_E_192 | Free fatty acids | -- | -- | | --//Activation//-- | Other | EPC | Blood | Type 2 diabetes mellitus | Accelerate | | L | 28786152 |
| Sen_E_193 | Curcumin | -- | -- | | Activation//Downregulation | Chemical compounds | VMSC | -- | Aging | Accelerate | | L | 31372798 |
| Sen_E_194 | 4,5-diphenyl-2-methyl picolinate | -- | -- | | Activation//Activation | Chemical compounds | MKN28 | -- | Gastric cancer | Accelerate | | L | 31639393 |
| Sen_E_195 | Hyperoxia | -- | -- | | --//-- | Other | PHLF | -- | Aging | Accelerate | | L | 18948382 |
| Sen_E_196 | TPL | -- | -- | | Upregulation//Activation//Downregulation | Chemical compounds | HepG2 | Liver | Aging | Accelerate | | L | 27878302 |
| Sen_E_197 | Ginsenoside Rg3 | -- | -- | | Upregulation//Activation | Chemical compounds | U87 | -- | Glioma | Accelerate | | L | 22922739 |
| Sen_E_198 | Dexamethasone | -- | -- | | -- | Chemical compounds | A549,NCI-H292 | Tumor tissue | Lung cancer | Prevent | | L | 23272171 |
| Sen_E_199 | Cisplatin | -- | -- | | Upregulation | Chemical compounds | A375 | -- | Melanoma | Accelerate | | L | 29449532 |
| Sen_E_200 | Dehydroleucodine | -- | -- | | Upregulation | Chemical compounds | HeLa S3,MCF-7 | -- | Cancer | Accelerate | | L | 23341930 |
| Sen_E_201 | 3-deazaneplanocin A | -- | -- | | Activation | Chemical compounds | HepG2 | -- | Aging | Accelerate | | HL | 28459194 |
| Sen_E_202 | 2,2'-Azobis(2-amidinopropane)dihydrochloride(AAPH) | -- | -- | | Activation | Chemical compounds | A375,NIH-3T3 | -- | Aging | Accelerate | | L | 30555576 |
| Sen_E_203 | Bufalin | -- | -- | | Upregulation | Chemical compounds | LNCaP | -- | Prostate cancer | Accelerate | | HL | 30166403 |
| Sen_E_204 | Centella asiatica | -- | -- | | Downregulation | Chemical compounds | HDF | -- | Aging | Prevent | | HL | 22092576 |
| Sen_E_205 | H2O2 | -- | -- | | Upregulation | Chemical compounds | HDF | -- | Aging | Accelerate | | HL | 22092576 |
| Sen_E_206 | Cisplatin | -- | -- | | Upregulation | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | L | 28888100 |
| Sen_E_207 | LA-12 | -- | -- | | Upregulation | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | L | 28888100 |
| Sen_E_208 | SCH900776 | -- | -- | | Upregulation | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | L | 28888100 |
| Sen_E_209 | 5AZA-dC | -- | -- | | Activation | Chemical compounds | U2OS | -- | Tumor | Accelerate | Others | L | 17389721 |
| Sen_E_210 | Doxorubicin | -- | -- | | Activation | Chemical compounds | MCF 10A | -- | Aging | Accelerate | Others | L | 18089808 |
| Sen_E_211 | Chronic low-dose rate gamma-radiation | -- | -- | | Activation | Other | HUVEC | -- | Cardiovascular disease | Accelerate | | L | 23349028 |
| Sen_E_212 | LMWP-SOD1 | -- | -- | | -- | Other | HDPSC | -- | Aging | Prevent | | L | 23049256 |
| Sen_E_213 | Ionizing radiation | -- | -- | | Activation | Other | NSCLC,H460,A549 | -- | Lung cancer | Accelerate | | L | 23683497 |
| Sen_E_214 | Cr | -- | -- | | Upregulation | Other | L-02 | -- | Aging | Accelerate | | L | 27698449 |
| Sen_E_215 | Simvastatin | -- | -- | | Upregulation//Upregulation | Chemical compounds | WM9 | -- | Melanoma | Accelerate | | L | 23933099 |
| Sen_E_216 | Wharton’s jelly extract | -- | -- | | Downregulation//Downregulation | Other | MSC | -- | Aging | Prevent | | L | 23516461 |
| Sen_E_217 | Nutlin-3a | -- | -- | | -- | Chemical compounds | U87 MG | Tumor tissue | Glioblastoma | Accelerate | | L | 21483692 |
| Sen_E_218 | Nutlin-3 | -- | -- | | -- | Chemical compounds | WI-38 | -- | Aging | Prevent | | L | 20157557 |
| Sen_E_219 | Nutlin-3a | -- | -- | | Activation | Chemical compounds | H460 | -- | Aging | Accelerate | | HL | 19737973 |
| Sen_E_220 | DmHsp22 | -- | -- | | Downregulation | Chemical compounds | TIG-1 | -- | Aging | Prevent | | L | 19948727 |
| Sen_E_221 | Nutlin-3a | -- | -- | | Activation | Chemical compounds | MyLa2000,SeAx,HuT 78,Mac2a | Plaque,Blood,Lymphoma | Cutaneous T-Cell Lymphoma | Accelerate | | L | 22377766 |
| Sen_E_222 | Nutlin-3a | -- | -- | | Activation | Chemical compounds | NSCLC,H460 | -- | Lung cancer | Accelerate | | L | 23683497 |
| Sen_E_223 | Nutlin-3 | -- | -- | | -- | Chemical compounds | SKN-SH | -- | Neuroblastoma | Accelerate | | L | 17018622 |
| Sen_E_224 | SAHA | -- | -- | | Activation | Chemical compounds | U87 MG | -- | Glioma | Accelerate | | L | 27863490 |
| Sen_E_225 | Rhus coriaria ethanolic extract | -- | -- | | Activation//Activation | Chemical compounds | MDA-MB-231 | -- | Breast cancer | Accelerate | | L | 26263881 |
| Sen_E_226 | UVA | -- | -- | | Upregulation//Upregulation//Upregulation | Other | Fibroblast | Koreskin | Aging | Accelerate | | L | 25039464 |
| Sen_E_227 | Red light | -- | -- | | Downregulation//Downregulation//Downregulation | Other | Fibroblast | Koreskin | Aging | Prevent | | L | 25039464 |
| Sen_E_228 | Acidic Ph | -- | -- | | Activation | Other | NP | Lumbar discs | Disc degenerative disease | Accelerate | | L | 30291218 |
| Sen_E_229 | Regulatory T(Treg)cells | -- | -- | | Activation//Activation//-- | Other | CD4+T | -- | Aging | Accelerate | | L | 22723548 |
| Sen_E_230 | Hepatocyte growth factor | -- | -- | | Activation//Activation//Activation | Chemical compounds | SKOV3,OVCAR-3,A2780 | -- | Ovarian cancer | Accelerate | | L | 28652056 |
| Sen_E_231 | Surfactant | -- | -- | | Activation | Other | TIG-7,CK,BK,FDPC | -- | Aging | Accelerate | | L | 25198914 |
| Sen_E_232 | 4-(4-fluorophenyl)-2-phenyl-5,6,7,8-tetrahydroquinoline | -- | -- | | Upregulation | Chemical compounds | IMR-90,A2780 | -- | Ovarian cancer | Accelerate | | L | 29143360 |
| Sen_E_233 | Doxorubicin | -- | -- | | Upregulation | Chemical compounds | SKN-SH | -- | Aging | Accelerate | | HL | 16557274 |
| Sen_E_234 | Supraphysiological and rogen | -- | -- | | --//-- | Other | LNCaP,C4-2 | Prostate | Prostate cancer | Accelerate | | L | 25216853 |
| Sen_E_235 | Doxorubicin | -- | -- | | Downregulation//Activation | Chemical compounds | S3R,S4,L5 | Spleen | Nijmegen Breakage Syndrome | Accelerate | | L | 25119968 |
| Sen_E_236 | SDB | -- | -- | | -- | Chemical compounds | HFF | Skin | Aging | Accelerate | | L | 15093749 |
| Sen_E_237 | senescence-messaging secretome factors | -- | -- | | Activation//Activation | Other | MESC | -- | Aging | Accelerate | | L | 29397942 |
| Sen_E_238 | Cholera toxin | -- | -- | | -- | Other | NHM-C,NHM-B | -- | Melanoma | Accelerate | | L | 10911949 |
| Sen_E_239 | DECM | -- | -- | | --//Upregulation//--//--//--//-- | Other | UC-MSC | -- | Aging | Prevent | | L | 28107614 |
| Sen_E_240 | Metformin | -- | -- | | --//-- | Chemical compounds | HDF | -- | Aging | Prevent | | L | 29659168 |
| Sen_E_241 | Terrein | -- | -- | | -- | Chemical compounds | HDF | -- | Aging | Prevent | | L | 26416516 |
| Sen_E_242 | Rapamycin | -- | -- | | Activation//-- | Chemical compounds | Fibroblast | Skin | Aging | Prevent | | HL | 28371119 |
| Sen_E_243 | Piceatannol | -- | -- | | Upregulation | Chemical compounds | Cortex cell,Hippocampus | Hippocampus,Cortical tissue | Aging | Prevent | | L | 29214257 |
| Sen_E_244 | Phenolic diterpenes carnosic acid | -- | -- | | Upregulation | Chemical compounds | ASF-2 | Mammary Gland | Aging | Prevent | | L | 25744415 |
| Sen_E_245 | Phenolic diterpenes carnosol | -- | -- | | Upregulation | Chemical compounds | ASF-2 | Mammary Gland | Aging | Prevent | | L | 25744415 |
| Sen_E_246 | Molecular hydrogen | -- | -- | | Activation | Other | HUVEC | -- | Aging | Prevent | | L | 27477846 |
| Sen_E_247 | Low oxygen | -- | -- | | Activation//Activation//Activation | Other | MIAMI | Bone marrow | Aging | Prevent | | HL | 27059084 |
| Sen_E_248 | Hypoxic | -- | -- | | Activation | Other | HADMPC | -- | Aging | Prevent | | L | 24878247 |
| Sen_E_249 | HFD | -- | -- | | Upregulation | Other | -- | Mice endothelium tissue | Cardiovascular disease | Accelerate | | L | 26164602 |
| Sen_E_250 | A2E | -- | -- | | Activation | Chemical compounds | RPE | -- | Age-related macular degeneration | Accelerate | | HL | 29415988 |
| Sen_E_251 | KF866 | -- | -- | | Downregulation | Chemical compounds | Hs68 | -- | Aging | Accelerate | | L | 26330291 |
| Sen_E_252 | U0126 | -- | -- | | Downregulation | Chemical compounds | HT-p21 | -- | Aging | Prevent | | L | 19478560 |
| Sen_E_253 | LY294002 | -- | -- | | Downregulation | Chemical compounds | HT-p21 | -- | Aging | Prevent | | L | 19478560 |
| Sen_E_254 | reconstituted HDL | -- | -- | | Activation | Other | CAC | -- | Aging | Prevent | | L | 21415389 |
| Sen_E_255 | Autophagy | -- | -- | | Activation | Other | WI-38 | -- | Aging | Accelerate | | L | 31931659 |
| Sen_E_256 | Rapamycin | -- | -- | | Downregulation | Chemical compounds | HUVEC | -- | Aging | Prevent | | HL | 29857052 |
| Sen_E_257 | TMAO | -- | -- | | Downregulation | Chemical compounds | -- | Hippocampus | Aging | Accelerate | | L | 29749694 |
| Sen_E_258 | Rapamycin | -- | -- | | Downregulation | Chemical compounds | PA-SMC,P-EC | -- | Chronic obstructive pulmonary disease | Prevent | | L | 29415880 |
| Sen_E_259 | Everolimus | -- | -- | | -- | Chemical compounds | HuT 102,MT2,CEM,Jurkat | -- | Adult T-cell leukemia/lymphoma | Accelerate | | L | 21064094 |
| Sen_E_260 | Hypoxia | -- | -- | | -- | Other | HT-p21-9 | -- | Aging | Prevent | | L | 22847439 |
| Sen_E_261 | ROS | -- | -- | | -- | Chemical compounds | IMR-90 | Liver | Aging | Accelerate | | HL | 32001510 |
| Sen_E_262 | Extracellular vesicles | -- | -- | | -- | Other | H9C2 | -- | Aging | Prevent | | L | 30499000 |
| Sen_E_263 | Salidroside | -- | -- | | -- | Chemical compounds | 2BS | -- | Aging | Prevent | | HL | 31612074 |
| Sen_E_264 | Avenanthramide A | -- | -- | | Activation | Chemical compounds | -- | Colon | Colorectal cancer | Accelerate | | L | 30888162 |
| Sen_E_265 | PAM | -- | -- | | -- | Chemical compounds | NHOK,NHOF | Oral cavity | Bisphosphonate-related osteonecrosis of the jaw | Accelerate | | L | 21427353 |
| Sen_E_266 | Gomisin A | -- | -- | | Downregulation | Chemical compounds | HDF | -- | Aging | Prevent | | L | 29319901 |
| Sen_E_267 | Gypenoside L | -- | -- | | Activation//Activation//Activation//Activation | Chemical compounds | ECA-109,HepG2 | -- | Aging | Accelerate | | L | 30889805 |
| Sen_E_268 | C2-ceramide | -- | -- | | Activation | Chemical compounds | H1299 | -- | Lung cancer | Accelerate | | L | 20624405 |
| Sen_E_269 | Melatonin | -- | -- | | Downregulation | Chemical compounds | IMR-90 | -- | Aging | Prevent | | HL | 28247536 |
| Sen_E_270 | Exosomes | -- | -- | | -- | Other | -- | Heart | Cardiovascular disease | Prevent | | L | 31089420 |
| Sen_E_271 | PQQ | -- | -- | | Activation | Chemical compounds | HK-2 | -- | Aging | Prevent | | L | 31035086 |
| Sen_E_272 | Dehydroepiandrosterone | -- | -- | | Activation | Chemical compounds | HAEC | -- | Aging | Prevent | | L | 26051603 |
| Sen_E_273 | Probucol | -- | -- | | Downregulation | Chemical compounds | HMC | -- | Aging | Prevent | | L | 23984931 |
| Sen_E_274 | pIFN- α | -- | -- | | -- | Chemical compounds | EA.hy926 | Tumor tissue | Melanoma | Accelerate | | L | 21197417 |
| Sen_E_275 | 27-hydroxycholesterol | -- | -- | | Activation | Chemical compounds | BV-2,PC-12 | -- | Neurodegenerative disease | Accelerate | | L | 28739487 |
| Sen_E_276 | Irradiation | -- | -- | | Upregulation | Other | -- | Submandibular Salivary Gland | Dry-mouth syndrome | Accelerate | | L | 26759233 |
| Sen_E_277 | Thiostrepton | -- | -- | | Downregulation | Chemical compounds | MCF-7,MDA-MB-436 | -- | Breast cancer | Accelerate | | L | 31322278 |
| Sen_E_278 | Fucoidan | -- | -- | | Activation | Chemical compounds | MSC | Adipose | Aging | Prevent | | L | 29642406 |
| Sen_E_279 | Estrogen | -- | -- | | Activation | Chemical compounds | B-MSC | -- | Osteoporosis | Prevent | | L | 29030963 |
| Sen_E_280 | Busulfan | -- | -- | | Activation | Chemical compounds | WI-38 | -- | Aging | Accelerate | | L | 17512465 |
| Sen_E_281 | Oxytocin | -- | -- | | Activation | Chemical compounds | NHDF | -- | Aging | Prevent | | HL | 30801661 |
| Sen_E_282 | Cisplatin | -- | -- | | Activation | Chemical compounds | EC109 | -- | Esophageal cancer | Accelerate | | L | 25236911 |
| Sen_E_283 | Crataegus extract | -- | -- | | -- | Other | Endothelial cell | -- | Aging | Prevent | | L | 26672612 |
| Sen_E_284 | Berberine | -- | -- | | Downregulation | Chemical compounds | U87 MG,U251MG | Tumor tissue | Glioblastoma | Accelerate | | L | 25504754 |
| Sen_E_285 | HCV infection | -- | -- | | -- | Other | CD4+T | Blood | HCV infection | Accelerate | | L | 27354409 |
| Sen_E_286 | BrdU | -- | -- | | -- | Chemical compounds | HeLa,A549 | -- | Aging | Accelerate | | L | 25416819 |
| Sen_E_287 | Camptothecin | -- | -- | | Activation//--//Activation | Chemical compounds | CRC | -- | Colorectal cancer | Accelerate | | L | 24858802 |
| Sen_E_288 | Dihydroartemisinin | -- | -- | | --//-- | Chemical compounds | HepG2.2.15 | Tumor tissue | Hepatocellular carcinoma | Accelerate | | L | 31383247 |
| Sen_E_289 | Pevonedistat | -- | -- | | -- | Chemical compounds | Melanoma cell | -- | Melanoma | Accelerate | | HL | 27333051 |
| Sen_E_290 | AZD6738 | -- | -- | | Upregulation | Chemical compounds | HeLa | -- | Colorectal cancer | Accelerate | | HL | 30532030 |
| Sen_E_291 | SHR6390 | -- | -- | | Downregulation | Chemical compounds | MCF-7,ZR-75-1 | Tumor tissue | Breast cancer | Accelerate | | L | 30724426 |
| Sen_E_292 | Copper | -- | -- | | Downregulation | Other | U87 MG | -- | Glioblastoma | Accelerate | | L | 23468063 |
| Sen_E_293 | EGCG | -- | -- | | Downregulation | Chemical compounds | 3T3-L0 | -- | Aging | Prevent | | L | 30456590 |
| Sen_E_294 | Cigarette smoke extract | -- | -- | | Activation//Activation//Activation | Other | HFL-1 | -- | Aging | Accelerate | | L | 16840774 |
| Sen_E_295 | γ-irradiation | -- | -- | | Activation | Other | TIG-3 p27 | -- | Aging | Accelerate | | L | 25093836 |
| Sen_E_296 | MLN8237 | -- | -- | | Activation//Activation | Chemical compounds | Hs294T | -- | Melanoma | Accelerate | | HL | 23180582 |
| Sen_E_297 | ST1968 | -- | -- | | Activation//Activation | Chemical compounds | A2780,KB | -- | Cancer | Accelerate | | L | 20042274 |
| Sen_E_298 | BIBR1532 | -- | -- | | Downregulation | Chemical compounds | Calu-3,A549 | -- | Lung cancer | Accelerate | | L | 31419512 |
| Sen_E_299 | Pterostilbene | -- | -- | | Activation | Chemical compounds | A549 | -- | Lung cancer | Accelerate | | HL | 27612029 |
| Sen_E_300 | 20A | -- | -- | | -- | Other | HeLa | -- | Cervical cancer | Accelerate | | HL | 30759257 |
| Sen_E_301 | AGEs | -- | -- | | Activation | Other | RTEC | -- | Diabetes kidney disease | Accelerate | | L | 25567807 |
| Sen_E_302 | Metformin | -- | -- | | Activation | Chemical compounds | -- | Tumor tissue | Hepatocellular carcinoma | Accelerate | | L | 28964787 |
| Sen_E_303 | Honokiol | -- | -- | | Activation | Chemical compounds | NPC | Nucleus pulposus | Disc degenerative disease | Prevent | | L | 30420619 |
| Sen_E_304 | 78c | -- | -- | | Activation//Downregulation//Downregulation | Chemical compounds | -- | Skeletal muscle tissue | Aging | Prevent | | L | 29719225 |
| Sen_E_305 | Metformin | -- | -- | | Activation | Chemical compounds | MSC | -- | Aging | Prevent | | HL | 30210899 |
| Sen_E_306 | Tea polyphenols | -- | -- | | Activation//-- | Other | HMSC | -- | Aging | Prevent | | L | 31089945 |
| Sen_E_307 | PBA | -- | -- | | -- | Chemical compounds | MCF-7 | -- | Aging | Accelerate | | L | 22548801 |
| Sen_E_308 | D-gal | -- | -- | | Upregulation | Chemical compounds | B-MSC | Bone marrow | Aging | Accelerate | Others | L | 29777434 |
| Sen_E_309 | Ascorbic acid | -- | -- | | Downregulation | Chemical compounds | B-MSC | Bone marrow | Aging | Prevent | Others | L | 29777434 |
| Sen_E_310 | Compound fuling granule | -- | -- | | Downregulation | Chemical compounds | HEY,SKOV3 | -- | Ovarian cancer | Accelerate | | HL | 28036353 |
| Sen_E_311 | SN-38 | -- | -- | | Activation//Activation | Chemical compounds | LS174T,HCT116 | -- | Colorectal cancer | Accelerate | | L | 26485768 |
| Sen_E_312 | Lactoferrin | -- | -- | | Activation | Chemical compounds | hMSC | -- | Aging | Prevent | | L | 28870012 |
| Sen_E_313 | Indoxyl sulfate | -- | -- | | Activation | Chemical compounds | HUVEC | -- | Chronic kidney disease | Accelerate | | L | 24727683 |
| Sen_E_314 | Kynurenine | -- | -- | | Upregulation | Chemical compounds | B-MSC | -- | Osteoporosis | Accelerate | | L | 31812582 |
| Sen_E_315 | Palbociclib | PHOSPHO-RB | Downregulation | | -- | Chemical compounds | SW 13 ,NCI-H295R | -- | Adrenocortical carcinomas | Accelerate | | HL | 29283884 |
| Sen_E_316 | Ribociclib | PHOSPHO-RB | Downregulation | | -- | Chemical compounds | SW 13 ,NCI-H295R | -- | Adrenocortical carcinomas | Accelerate | | HL | 29283884 |
| Sen_E_317 | TPA | PERK1/2 | -- | | -- | Chemical compounds | HDF | -- | Aging | Prevent | | L | 25725291 |
| Sen_E_318 | Adriamycin | PERK//P53//RKIP | Downregulation//Upregulation//Upregulation | | -- | Chemical compounds | MEF | -- | Aging | Accelerate | | L | 23814485 |
| Sen_E_319 | H2O2 | PCNA | Downregulation | | -- | Chemical compounds | HDF,IMR-90 | -- | Aging | Accelerate | | L | 22819841 |
| Sen_E_320 | H2O2 | PARP//SIRT1//P53 | --//--//-- | | -- | Chemical compounds | TIG-3 | -- | Aging | Accelerate | | L | 17595514 |
| Sen_E_321 | Cigarette smoke | PARKIN | -- | | -- | Other | SAEC,fibroblast | Lung | Chronic obstructive pulmonary disease | Accelerate | | L | 25792665 |
| Sen_E_322 | UVB | P66SHC//FKHRL1 | Upregulation//Upregulation | | -- | Other | HDF | -- | Aging | Accelerate | | L | 20211546 |
| Sen_E_323 | OX-LDL | P62//SIRT1 | Upregulation//Downregulation | | -- | Chemical compounds | HUVEC | Umbilical cord | Cardiovascular disease | Accelerate | | L | 31658172 |
| Sen_E_324 | Doxorubicin | P53//γH2AX//P21 | Upregulation//Activation//Upregulation | | -- | Chemical compounds | NCI-H292 | -- | Aging | Accelerate | | L | 27836734 |
| Sen_E_325 | KR12 | P53//γH2AX | --//-- | | -- | Chemical compounds | LS180 | -- | Colorectal cancer | Accelerate | | L | 25913614 |
| Sen_E_326 | Vildagliptin | P53//SIRT1//AMPK | --//--//-- | | -- | Chemical compounds | Human primary Chondrocyte | -- | Osteoarthritis | Prevent | | L | 31026379 |
| Sen_E_327 | Cigarette smoke extract | P53//SIRT1 | Downregulation//Downregulation | | -- | Other | BEAS-2B | Lung | Aging | Accelerate | | L | 27413169 |
| Sen_E_328 | Aldosterone | P53//P21//SIRT1 | Upregulation//Upregulation//Downregulation | | -- | Chemical compounds | HPTC | Kidney | Aging | Accelerate | | L | 21190955 |
| Sen_E_329 | Cisplatin | P53//P21//SIRT1 | Upregulation//Upregulation//Downregulation | | -- | Chemical compounds | NRK | -- | Chronic kidney disease | Accelerate | | L | 30447351 |
| Sen_E_330 | Methoxyamine | P53//P21//RB | Upregulation//Upregulation//Activation | | -- | Chemical compounds | RKO | -- | Colorectal cancer | Accelerate | | L | 16648559 |
| Sen_E_331 | TC-G 1008 | P53//P21//PAI-1 | Downregulation//Downregulation//Downregulation | | -- | Chemical compounds | SW 13 53,Caco-2 | -- | Osteoarthritis | Prevent | | L | 31237151 |
| Sen_E_332 | Resveratrol | P53//P21//P38MAPK//ATM | --//--//--//Activation | | -- | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | L | 17626009 |
| Sen_E_333 | Curcumin | P53//P21 | Upregulation//Upregulation | | -- | Chemical compounds | MCF-7,U2OS | -- | Aging | Accelerate | | L | 22613224 |
| Sen_E_334 | H2O2 | P53//P21 | Upregulation//Upregulation | | -- | Chemical compounds | ADSC | -- | Aging | Accelerate | | L | 25654692 |
| Sen_E_335 | Pigment epithelium-derived factor | P53//P16 | Downregulation//Downregulation | | -- | Other | MSC | -- | Aging | Prevent | | L | 23359450 |
| Sen_E_336 | Scopoletin | P53//NF-κB//NRF2//P-FOXO1 | Activation//Downregulation//Upregulation//Upregulation | | -- | Chemical compounds | IMR-90 | -- | Aging | Prevent | | L | 25837273 |
| Sen_E_337 | Nutlin-3a | P53//MIR-34A//MIR-34B//MIR-34//ING2 | Activation//Upregulation//Upregulation//Upregulation//Downregulation | | -- | Chemical compounds | Fibroblast,GM08402,NHF-hTERT,IMR-90,MRC-5 | -- | Aging | Accelerate | | HL | 18451145 |
| Sen_E_338 | Nutlin-3 | P53//MDM2//P21 | Upregulation//Upregulation//Upregulation | | -- | Chemical compounds | ACHN,Caki-2,RCC | -- | Renal carcinoma | Accelerate | | L | 25067787 |
| Sen_E_339 | Nutlin-3 | P53 | Activation | | -- | Chemical compounds | CADO-ES-1 | -- | Sarcoma | Accelerate | | L | 21334198 |
| Sen_E_340 | low-Dox | P53 | Upregulation | | -- | Chemical compounds | WI-38 | -- | Aging | Accelerate | | L | 21051933 |
| Sen_E_341 | PTP | P53 | Upregulation | | -- | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | L | 25338966 |
| Sen_E_342 | Doxorubicin | P53 | -- | | -- | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | HL | 26840028 |
| Sen_E_343 | ABT-263 | P53 | -- | | -- | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | L | 28533436 |
| Sen_E_344 | Metformin | P53 | -- | | -- | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | L | 28533436 |
| Sen_E_345 | Formaldehyde | P53 | Upregulation | | -- | Chemical compounds | IMR-90 | -- | Aging | Accelerate | | L | 22722496 |
| Sen_E_346 | Irradiation | P53 | Upregulation | | -- | Other | LNCaP,22Rv1 | -- | Prostate cancer | Accelerate | | L | 17351335 |
| Sen_E_347 | Simvastatin | P38MAPK | Downregulation | | -- | Chemical compounds | -- | Embryo | Aging | Prevent | | L | 29911323 |
| Sen_E_348 | Rosuvastatin | P38MAPK | Downregulation | | -- | Chemical compounds | -- | Embryo | Aging | Prevent | | L | 29911323 |
| Sen_E_349 | 5‐FU | P38//JNK//ENOS//SIRT1 | --//--//Downregulation//Downregulation | | -- | Chemical compounds | EA.hy926 | -- | Aging | Accelerate | | L | 28127745 |
| Sen_E_350 | LGX818 | P27//PRB | Upregulation//Activation | | -- | Chemical compounds | A375,G-361,SK-MEL-24 | -- | Melanoma | Accelerate | | L | 26586345 |
| Sen_E_351 | Rivaroxaban | P22PHOX//ICAM//VCAM1//PAR1 | Downregulation//Downregulation//Downregulation//Downregulation | | -- | Chemical compounds | HUVEC | -- | Atherosclerosis | Prevent | | L | 31266015 |
| Sen_E_352 | Oxidative stress | P21//TRF1//TRF2//SIRT1//XRCC5 | Upregulation//Downregulation//Upregulation//Upregulation//Upregulation | | -- | Other | MSC | -- | Aging | Accelerate | | L | 21376036 |
| Sen_E_353 | MCF-7 mammospheres | P21//PRB | Downregulation//Downregulation | | -- | Other | MCF-7 | -- | Breast cancer | Prevent | | L | 20525204 |
| Sen_E_354 | Argentatin B | P21//P27 | Upregulation//Upregulation | | -- | Chemical compounds | HCT-15,PC-3 | -- | Aging | Accelerate | | L | 26633316 |
| Sen_E_355 | MLN4924 | P21//P27 | --//-- | | -- | Chemical compounds | Lymphoma cell line | -- | Lymphoma | Accelerate | | HL | 25782162 |
| Sen_E_356 | Polyphenols of Artichoke(Cynara scolymus L.)Exerts | P21//P16 | Upregulation//Upregulation | | -- | Other | MDA-MB-231,ASC | Adipose | Breast cancer | Accelerate | | L | 26180585 |
| Sen_E_357 | PMA | P21//CYCLIN D1 | Activation//Activation | | -- | Chemical compounds | SK-BR-3 | -- | Aging | Accelerate | | L | 25587030 |
| Sen_E_358 | AMG 900+HDACI | P21 | Upregulation | | -- | Chemical compounds | PCA | -- | Prostate cancer | Accelerate | | L | 24989836 |
| Sen_E_359 | Pioglitazone and Melatonin | P21 | Downregulation | | -- | Chemical compounds | MSC | -- | Aging | Prevent | | L | 29734669 |
| Sen_E_360 | RD | P21 | -- | | -- | Chemical compounds | PCa,DU 145 | -- | Prostate cancer | Accelerate | | L | 24322375 |
| Sen_E_361 | H2O2 | P21 | Upregulation | | -- | Chemical compounds | HeLa | -- | Cervical cancer | Accelerate | | L | 12565825 |
| Sen_E_362 | MLN4924 | P21 | Upregulation | | -- | Chemical compounds | HCT116,H1299,U87 | -- | Cancer | Accelerate | | L | 21677879 |
| Sen_E_363 | BI-D1870 | P21 | Upregulation | | -- | Chemical compounds | HCT116,MCF-7 | -- | Cancer | Accelerate | | L | 24136223 |
| Sen_E_364 | H2O2 | P21 | Upregulation | | -- | Chemical compounds | HMESC | Blood | Aging | Accelerate | | L | 24062878 |
| Sen_E_365 | Heat shock | P21 | Upregulation | | -- | Other | MSC | Blood | Aging | Accelerate | | L | 24078383 |
| Sen_E_366 | Nicotinamide | P16//SIRT1//P38 | Upregulation//Downregulation//-- | | -- | Chemical compounds | UC-MSC | -- | Aging | Accelerate | | L | 28107614 |
| Sen_E_367 | TBK1-II | P16//P65-NFκB | Activation//-- | | -- | Chemical compounds | HCC1954,SK-BR-3,Neu monolayer cell | Mammary Gland | Aging | Accelerate | | HL | 24487029 |
| Sen_E_368 | 5-Aza-20-Deoxycytidine | P16//P53 | Upregulation//Upregulation | | -- | Chemical compounds | HepG2,Hep3B | -- | Cancer | Accelerate | | HL | 23924947 |
| Sen_E_369 | Arid1B | P16//P21A//P53 | Upregulation//Upregulation//Upregulation | | -- | Chemical compounds | MEF | -- | Hepatocellular carcinoma | Accelerate | | HL | 27737960 |
| Sen_E_370 | Teng-Long-Bu-Zhong-Tang | P16//P21//RB | Upregulation//Upregulation//Downregulation | | -- | Chemical compounds | CT26 | -- | Colorectal cancer | Accelerate | | L | 23758730 |
| Sen_E_371 | NE | P16//CDK4 | Upregulation//Downregulation | | -- | Chemical compounds | NHBE | -- | Cystic Fibrosis | Accelerate | | L | 23316069 |
| Sen_E_372 | BBR | P16 | Upregulation | | -- | Chemical compounds | -- | Mammary Gland | Breast cancer | Accelerate | | L | 26168818 |
| Sen_E_373 | NAX014 | P16 | Upregulation | | -- | Chemical compounds | -- | Mammary Gland | Breast cancer | Accelerate | | L | 26168818 |
| Sen_E_374 | H2O2 | P16 | -- | | -- | Chemical compounds | WI-38 | -- | Aging | Accelerate | | L | 28120917 |
| Sen_E_375 | Cigarette smoke | OXPHOS | Downregulation | | -- | Other | SAEC,NHBE | -- | Aging | Accelerate | | L | 31593750 |
| Sen_E_376 | High glucose | OPTN | Downregulation | | -- | Other | RTEC | -- | Aging | Accelerate | | L | 29367621 |
| Sen_E_377 | Etoposide | OCT4A//P21//P53//P16 | Activation//Upregulation//Upregulation//-- | | -- | Chemical compounds | PA-1 | -- | Embryonal carcinoma | Accelerate | | L | 26102294 |
| Sen_E_378 | RSV | NUCLEOSIDES//P53//CXCR2 | --//--//-- | | -- | Chemical compounds | U2OS | -- | Aging | Accelerate | | L | 28303009 |
| Sen_E_379 | Salicin | NRF2 | -- | | -- | Chemical compounds | HUVEC | -- | Vascular disease | Prevent | | L | 31220953 |
| Sen_E_380 | Low dose Emodin | NRARP | Downregulation | | -- | Other | MCF-7 | -- | Breast cancer | Accelerate | | L | 30274778 |
| Sen_E_381 | Nucleus accumbens-1 | NP63 | -- | | -- | Other | SKOV3/N130,HeLa/N130 | -- | Aging | Prevent | | L | 22665267 |
| Sen_E_382 | H2O2 | NOX4//TRX-1//CATHEPSIN D | Upregulation//Downregulation//Activation | | -- | Chemical compounds | Endothelial cell | -- | Cardiovascular disease | Accelerate | | L | 24632182 |
| Sen_E_383 | AngII | NOX2//NOX4//NOX5 | Upregulation//Upregulation//Upregulation | | -- | Chemical compounds | MNC | Blood | Aging | Accelerate | | L | 21841319 |
| Sen_E_384 | GATA4 | NF-κB | Activation | | -- | Chemical compounds | Fibroblast,IMR-90 | -- | Aging | Accelerate | | HL | 26404840 |
| Sen_E_385 | Cyanidin | NF-KB//INOS//COX-2 | Downregulation//Downregulation//Downregulation | | -- | Chemical compounds | WI-38 | -- | Aging | Prevent | | L | 20190403 |
| Sen_E_386 | Galangin | NF-KB | Downregulation | | -- | Chemical compounds | Hs68 | -- | Aging | Prevent | | L | 28834114 |
| Sen_E_387 | Atorvastatin | NBS-1//HDM2 | --//Upregulation | | -- | Chemical compounds | VSMC | -- | Atherosclerosis | Prevent | | L | 18723444 |
| Sen_E_388 | FK866 | NAD+//SIRT1 | Downregulation//Downregulation | | -- | Chemical compounds | ARPE?19 | -- | Retinal disease | Accelerate | | L | 29905535 |
| Sen_E_389 | Nicotinamide mononucleotide | NAD+//SIRT1 | Upregulation//Upregulation | | -- | Chemical compounds | ARPE?19 | -- | Aging | Prevent | | L | 29905535 |
| Sen_E_390 | Rapamycin | MTERT | Upregulation | | -- | Chemical compounds | REF | -- | Aging | Prevent | | L | 24296616 |
| Sen_E_391 | Embonic acid | M-NAD(P)-ME | Downregulation | | -- | Other | H1299 | -- | Aging | Accelerate | | L | 26008970 |
| Sen_E_392 | Lithium | MMP1//PAI-1 | Upregulation//Upregulation | | -- | Other | BAEC | -- | Cardiovascular disease | Accelerate | | L | 19407340 |
| Sen_E_393 | H2O2 | MITF//NRF2 | Downregulation//Upregulation | | -- | Chemical compounds | HEMn | -- | Aging | Accelerate | | L | 30805890 |
| Sen_E_394 | DOX | MIR-375 | Upregulation | | -- | Chemical compounds | K562 | -- | Aging | Accelerate | | HL | 22606351 |
| Sen_E_395 | MIF | MIR-34A | Downregulation | | -- | Chemical compounds | HCM | -- | Aging | Prevent | | L | 30226567 |
| Sen_E_396 | Radiation | MIR-34A | Upregulation | | -- | Other | HCM | -- | Aging | Accelerate | | L | 30226567 |
| Sen_E_397 | Lipid lowering therapy | MIR-23A//TRF2 | Downregulation//Upregulation | | -- | Other | PBMC | Blood | Coronary artery disease | Prevent | | HL | 28646123 |
| Sen_E_398 | PTC-209 | MIR-200C//MIR-141 | Upregulation//Upregulation | | -- | Chemical compounds | MRC-5,MCF-7,MDA-MB-231 | -- | Aging | Accelerate | | L | 27105531 |
| Sen_E_399 | Busulfan | MIR-200A//MIR-200B//MIR-200C//MIR-141//MIR-429//ZEB1//ZEB2 | Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Downregulation//Downregulation | | -- | Chemical compounds | U2OS,MG-63 | -- | Osteosarcoma | Accelerate | | L | 24815002 |
| Sen_E_400 | 21% O2 | MIR-181A//MMP1//COL1A1 | Downregulation//Upregulation//Downregulation | | -- | Other | HDF | -- | Aging | Accelerate | | L | 30405877 |
| Sen_E_401 | Simvastatin | MIR-156 | Downregulation | | -- | Chemical compounds | HUVEC | -- | Atherosclerosis | Prevent | | L | 31752013 |
| Sen_E_402 | Valsartan | MIR-155 | Downregulation | | -- | Chemical compounds | HUVEC | -- | Atherosclerosis | Prevent | | L | 31752013 |
| Sen_E_403 | UNC2025 | MERTK | -- | | -- | Chemical compounds | A172,SF188,U251 | -- | Glioblastoma | Accelerate | | L | 27783662 |
| Sen_E_404 | Rapamycin | LC3-II//P62 | Upregulation//Downregulation | | -- | Chemical compounds | Fibroblast | -- | Werner syndrome | Prevent | | L | 24308646 |
| Sen_E_405 | Adhesion molecule on glia | L1 | -- | | -- | Other | U87 MG | -- | Glioma | Accelerate | | HL | 31510944 |
| Sen_E_406 | Radiation | KU86//P16 | Downregulation//Upregulation | | -- | Other | HUVEC | -- | Aging | Accelerate | | L | 30616437 |
| Sen_E_407 | Ang II | KLOTHO | Downregulation | | -- | Chemical compounds | EPC | -- | Aging | Accelerate | | HL | 20832068 |
| Sen_E_408 | CGRP | KLOTHO | Upregulation | | -- | Chemical compounds | EPC | -- | Aging | Prevent | | HL | 20832068 |
| Sen_E_409 | RUT | KLOTHO | Upregulation | | -- | Chemical compounds | EPC | -- | Aging | Prevent | | HL | 20832068 |
| Sen_E_410 | 1,25(OH)2D3 | KDM6B | Upregulation | | -- | Chemical compounds | U87,U251 | -- | Glioma | Accelerate | | L | 30825201 |
| Sen_E_411 | HDAC inhibitor(sodium butyrate(NaBu) and valproic acid(VPA)) | JMJD3//P16//SUZ12//BMI1//EZH2//C-MYC | Upregulation//Upregulation//Downregulation//Downregulation//Downregulation//Downregulation | | -- | Chemical compounds | AD-MSC,UCB-MSC | Blood,Adipose | Aging | Accelerate | | L | 20049504 |
| Sen_E_412 | Hydrogen sulfide | IL-8//SRSF2//HNRNPD | Upregulation//Upregulation//Upregulation | | -- | Chemical compounds | Aortic Endothelial cell | -- | Aging | Prevent | | L | 30026406 |
| Sen_E_413 | Doxycycline | IKBζ | Upregulation | | -- | Chemical compounds | MCF-7 | -- | Aging | Accelerate | | L | 23781024 |
| Sen_E_414 | Bleomycin | IKBζ | Upregulation | | -- | Chemical compounds | MCF-7 | -- | Aging | Accelerate | | L | 23781024 |
| Sen_E_415 | Ionizing radiation | IKBζ | Upregulation | | -- | Other | MCF-7 | -- | Aging | Accelerate | | L | 23781024 |
| Sen_E_416 | Fluidic substrate | IGFBP5//P53 | Upregulation//Upregulation | | -- | Other | NCI-H23 | -- | Lung cancer | Accelerate | | L | 29187894 |
| Sen_E_417 | PGE2 | IGFBP5 | Upregulation | | -- | Chemical compounds | HDF | -- | Aging | Accelerate | | HL | 21191810 |
| Sen_E_418 | Ionizing radiation | IGFBP5 | -- | | -- | Other | HUVEC | -- | Aging | Accelerate | | HL | 24164458 |
| Sen_E_419 | Homocysteine | HTERT | Downregulation | | -- | Chemical compounds | HUVEC | Aorta | Aging | Accelerate | | L | 25359865 |
| Sen_E_420 | CO | HO-1//ENOS//SIRT1 | Upregulation//Upregulation//Upregulation | | -- | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 31704100 |
| Sen_E_421 | β-Hydroxybutyrate | HNRNPA1//OCT4A | Downregulation//Upregulation | | -- | Chemical compounds | HUVEC,HASMC | -- | Aging | Prevent | | L | 30197300 |
| Sen_E_422 | Hypoxia | HIF-1A//MIF | Activation//Upregulation | | -- | Other | IMR-90 | -- | Aging | Prevent | | L | 24984035 |
| Sen_E_423 | tris-C60 | HERC5//P16//P21//P53 | Downregulation//Upregulation//Upregulation//Upregulation | | -- | Chemical compounds | HEK | -- | Aging | Accelerate | | HL | 20045429 |
| Sen_E_424 | Costunolide | GS(P)//TKT | Downregulation//Downregulation | | -- | Chemical compounds | A172,U87 MG | -- | Glioblastoma | Accelerate | | HL | 27148686 |
| Sen_E_425 | Malignant ascitic fluids | GRO-1//HGF | Upregulation//Upregulation | | -- | Other | HPMC,A2780,SKOV3 | Retina | Ovarian cancer | Accelerate | | L | 27444787 |
| Sen_E_426 | X-ray | G-H2AX//P53//P21/CP1 | Upregulation//Upregulation//Upregulation | | -- | Other | Saos-2 | Bone | Aging | Accelerate | | L | 25293814 |
| Sen_E_427 | CS extract | GDF15 | -- | | -- | Other | HTBE | -- | Aging | Accelerate | | HL | 27093475 |
| Sen_E_428 | Propolis extrac | FOXO3A//NGF | Upregulation//Upregulation | | -- | Other | HDF | -- | Aging | Prevent | | L | 28826096 |
| Sen_E_429 | UVB irradiation | FOXO3A | Upregulation | | -- | Other | HDF | -- | Aging | Accelerate | | L | 28826096 |
| Sen_E_430 | AMG 232+radiation | FOXM1 | Downregulation | | -- | Other | H460,A549,HCT116,A375,SJSA-1,MCF-7,H226 | Lung,Colon,Melanoma,Mammary Gland | Cancer | Accelerate | | L | 26162687 |
| Sen_E_431 | DFO | FIS1 | Downregulation | | -- | Chemical compounds | Chang | -- | Aging | Accelerate | | L | 16883569 |
| Sen_E_432 | Hecogenin | ERK1/2//MMP2 | --//-- | | -- | Chemical compounds | A549 | -- | Lung cancer | Accelerate | | L | 25115457 |
| Sen_E_433 | Metformin | DICER1 | Upregulation | | -- | Chemical compounds | WI-38,IMR-90 | -- | Aging | Prevent | | HL | 26990999 |
| Sen_E_434 | Etoposide | DDR//P53//PRODH//DAO | --//--//--//-- | | -- | Chemical compounds | HepG2 | -- | Aging | Accelerate | | HL | 27545311 |
| Sen_E_435 | 3×mAbs | DCR2//P16//P21//P27/KIP | Upregulation//Upregulation//Upregulation//Upregulation | | -- | Chemical compounds | PC-9,H1975 | -- | Lung cancer | Accelerate | | L | 29212784 |
| Sen_E_436 | U0126 | CYCLIN D1 | Upregulation | | -- | Chemical compounds | HT-p16,HT-p21,MEL10 | -- | Glaucoma | Accelerate | | L | 23852369 |
| Sen_E_437 | PD0332991 | CYCLIN D1 | Upregulation | | -- | Chemical compounds | MEL10,RPE | -- | Glaucoma | Accelerate | | L | 23852369 |
| Sen_E_438 | Rapamycin | CYCLIN D1 | Downregulation | | -- | Chemical compounds | MEL10,RPE | -- | Glaucoma | Prevent | | L | 23852369 |
| Sen_E_439 | MLN4924 | CRL | Upregulation | | -- | Chemical compounds | QBC939,RBE | -- | Intrahepatic cholangiocarcinoma | Accelerate | | HL | 25229838 |
| Sen_E_440 | NS-398 | COX-2//P53//PCNA//MMP1 | Downregulation//Downregulation//--//Downregulation | | -- | Chemical compounds | Fibroblast | -- | Aging | Prevent | | L | 15130753 |
| Sen_E_441 | GSE24.2 | C-MYC//TERT | Activation//Activation | | -- | Other | F9-A353V,DC-C,DC-3,XDC1787-C,F26IIB | -- | Dyskeratosis congenita | Prevent | | L | 26571381 |
| Sen_E_442 | GSE4 | C-MYC//TERT | Activation//Activation | | -- | Other | F9-A353V,DC-C,DC-3,XDC1787-C,F26IIB | -- | Dyskeratosis congenita | Prevent | | L | 26571381 |
| Sen_E_443 | Palbociclib | CDK4/6//P53 | Downregulation//Upregulation | | -- | Chemical compounds | AGS,MKN45 | -- | Gastric cancer | Accelerate | | L | 28947133 |
| Sen_E_444 | Valproic acid | CDK4 | Downregulation | | -- | Chemical compounds | D283-MED,Daoy | -- | Medulloblastoma | Accelerate | | L | 16373706 |
| Sen_E_445 | CGN | CDK4 | Downregulation | | -- | Chemical compounds | HT29,SW480 ,NCM460 | -- | Colorectal cancer | Accelerate | | L | 29484762 |
| Sen_E_446 | Ionizing radiation | CDC6 | Upregulation | | -- | Other | CNE-2,U2OS | -- | Nasopharyngeal carcinoma | Accelerate | | L | 30158672 |
| Sen_E_447 | H2O2 | CAVEOLIN-1//P53 | Activation//Activation | | -- | Chemical compounds | NIH-3T3 | -- | Aging | Accelerate | | L | 12134086 |
| Sen_E_448 | Resveratrol/quercetin | CASPASE-3/7 | Activation | | -- | Chemical compounds | C6 | -- | Glioma | Accelerate | | L | 19496785 |
| Sen_E_449 | Resveratrol | BRCA1 | Upregulation | | -- | Chemical compounds | U2OS,A549 | -- | Cancer | Accelerate | | L | 19559722 |
| Sen_E_450 | ZF1 | BMI1//P53//P21 | Upregulation//Downregulation//Downregulation | | -- | Other | ASC | Adipose,Bone marrow,Dental pulp,Perinatal tissue | Aging | Prevent | | L | 31146388 |
| Sen_E_451 | Timosaponin A-III | BMI1 | Downregulation | | -- | Chemical compounds | MCF-7,MDA-MB-231 | -- | Aging | Accelerate | | L | 29528145 |
| Sen_E_452 | JQ1 | BET BROMODOMAIN | Inhibition | | -- | Chemical compounds | MM.1S | -- | Aging | Accelerate | | HL | 21889194 |
| Sen_E_453 | C-1311 | BECLIN1//ATG5 | --//-- | | -- | Chemical compounds | A549,H460 | -- | Lung cancer | Accelerate | | L | 23823138 |
| Sen_E_454 | TBHP | BCL-2//BAX//STAT1//STAT3 | Downregulation//Upregulation//Activation//Activation | | -- | Chemical compounds | HMC | -- | Aging | Accelerate | | L | 23984931 |
| Sen_E_455 | Idebenone | BAX//BCL-2 | Downregulation//Upregulation | | -- | Chemical compounds | ARPE?19 | -- | Aging | Prevent | | L | 26044821 |
| Sen_E_456 | photosensitizer 8-methoxy-psoralen and ultraviolet A radiation | ATR | Activation | | -- | Other | Fibroblast | -- | Aging | Accelerate | | L | 16436511 |
| Sen_E_457 | Telomeric plasmid | ATM//P53//TRF1//TRF2 | --//Upregulation//Upregulation//Upregulation | | -- | Other | MGC803 | -- | Gastric cancer | Accelerate | | L | 20535839 |
| Sen_E_458 | Nitric oxide | ATM | Activation | | -- | Chemical compounds | HeLa,MRC-5 | -- | Aging | Accelerate | | L | 27845209 |
| Sen_E_459 | Selenium Compounds | ATM | -- | | -- | Chemical compounds | MRC-5,CRL-1790,PC-3,HCT116 | -- | Cancer | Accelerate | | L | 20157118 |
| Sen_E_460 | MNNG | APC | Downregulation | | -- | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | L | 14728717 |
| Sen_E_461 | Ceramide | AP1//RB | --//-- | | -- | Chemical compounds | WI-38,HDF | -- | Aging | Accelerate | | L | 8530509 |
| Sen_E_462 | Metformin | AMPKα//HTERT//SIRT1//DOT-1L | Activation//Upregulation//Upregulation//Upregulation | | -- | Chemical compounds | HAEC | -- | Aging | Prevent | | L | 29366775 |
| Sen_E_463 | Ethanol | ALDH2 | Activation | | -- | Chemical compounds | Endothelial cell | -- | Atherosclerosis | Prevent | | L | 30885430 |
| Sen_E_464 | Doxorubicin | AGO2 | -- | | -- | Chemical compounds | MCF-7 | -- | Cancer | Accelerate | | L | 30476917 |
| Sen_E_465 | IFN-γ | AGO2 | -- | | -- | Chemical compounds | MCF-7 | -- | Cancer | Accelerate | | L | 30476917 |
| Sen_E_466 | TNF | AGO2 | -- | | -- | Chemical compounds | MCF-7 | -- | Cancer | Accelerate | | L | 30476917 |
| Sen_E_467 | TMZ | 3-MA | -- | | -- | Chemical compounds | LN-229,U87 MG | -- | Aging | Accelerate | | L | 23383259 |
| Sen_E_468 | Genistein | P66SHC//FKHRL1 | Downregulation//Downregulation | | -- | Chemical compounds | HDF | -- | Aging | Prevent | | L | 20211546 |
| Sen_E_469 | Purple sweet potato color | NLRP3 | Downregulation | | -- | Other | -- | Mice endothelium tissue | Cardiovascular disease | Prevent | | L | 26164602 |
| Sen_E_470 | 5-FU | -- | -- | | -- | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | HL | 29053388 |
| Sen_E_471 | OXA | -- | -- | | -- | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | HL | 29053388 |
| Sen_E_472 | IRINO | -- | -- | | -- | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | HL | 29053388 |
| Sen_E_473 | Doxorubicin | -- | -- | | -- | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | L | 28030837 |
| Sen_E_474 | Methylene blue | -- | -- | | -- | Chemical compounds | IMR-90 | Liver | Aging | Prevent | | L | 17928358 |
| Sen_E_475 | Doxorubicin | -- | -- | | -- | Chemical compounds | MCF-7 | -- | Breast cancer | Accelerate | | L | 21881167 |
| Sen_E_476 | 4 hydroxytamoxifen | -- | -- | | -- | Chemical compounds | MCF-7 | -- | Breast cancer | Accelerate | | L | 21881167 |
| Sen_E_477 | Cilostazol | -- | -- | | -- | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 19520256 |
| Sen_E_478 | Cysteamine | -- | -- | | -- | Chemical compounds | ARPE?19 | -- | Aging | Prevent | | L | 28767736 |
| Sen_E_479 | Fisetin | -- | -- | | -- | Chemical compounds | ARPE?19 | -- | Aging | Prevent | | L | 28767736 |
| Sen_E_480 | Tc52 | -- | -- | | -- | Chemical compounds | VH7 | -- | Aging | Accelerate | | L | 27412346 |
| Sen_E_481 | Gemcitabine | -- | -- | | -- | Chemical compounds | Miapaca-2,PANC-1 | Tumor tissue | Patients with pancreatic ductal adenocarcinoma | Accelerate | | L | 27311854 |
| Sen_E_482 | Doxorubicin | -- | -- | | -- | Chemical compounds | HCT116,H1299 | -- | Colorectal cancer | Accelerate | | L | 29352261 |
| Sen_E_483 | Rg3 | -- | -- | | -- | Chemical compounds | Chondrocyte | Bone | Osteoarthritis | Prevent | | L | 22454193 |
| Sen_E_484 | EGCG+SFN25 | -- | -- | | -- | Chemical compounds | HT29 | -- | Colorectal cancer | Prevent | | L | 17657594 |
| Sen_E_485 | Urolithin A | -- | -- | | -- | Chemical compounds | HSF | -- | Aging | Prevent | | L | 30215291 |
| Sen_E_486 | PD-0332991 | -- | -- | | -- | Chemical compounds | MCF-7,LCC9 | -- | Aging | Accelerate | | HL | 21367843 |
| Sen_E_487 | Pyocyanin | -- | -- | | -- | Chemical compounds | HepG2 | -- | Hepatocellular carcinoma | Accelerate | | L | 24461061 |
| Sen_E_488 | Sulforaphane | -- | -- | | -- | Chemical compounds | MCF-7,SK-BR-3,MDA-MB-231 | -- | Breast cancer | Accelerate | | HL | 28912888 |
| Sen_E_489 | Palbociclib | -- | -- | | -- | Chemical compounds | HuH-7,SK-HEP-1 | Patient-derived HCC tissue | Hepatocellular carcinoma | Accelerate | | L | 27849562 |
| Sen_E_490 | 6-diazo-5-oxo-L-norleucine | -- | -- | | -- | Chemical compounds | HUVEC | -- | Aging | Accelerate | | L | 18317946 |
| Sen_E_491 | Doxorubicin | -- | -- | | -- | Chemical compounds | A549,MCF-7 | -- | Aging | Accelerate | | L | 23612976 |
| Sen_E_492 | CANE | -- | -- | | -- | Chemical compounds | A549DR,A549 | -- | Lung cancer | Accelerate | | L | 29405784 |
| Sen_E_493 | Doxorubicin | -- | -- | | -- | Chemical compounds | MKN28 | -- | Gastric cancer | Accelerate | | L | 24738879 |
| Sen_E_494 | Doxorubicin | -- | -- | | -- | Chemical compounds | HEC-1B,Ishikawa | -- | Endometrioid adenocarcinoma | Accelerate | | L | 20372780 |
| Sen_E_495 | Curcumin | -- | -- | | -- | Chemical compounds | MCF-7,HCT116 | -- | Cancer | Accelerate | | L | 26916504 |
| Sen_E_496 | Disulfiram and doxorubicin | -- | -- | | -- | Chemical compounds | MDA-MB-231 | -- | Breast cancer | Accelerate | | L | 23974104 |
| Sen_E_497 | Condurango-glycoside-A | -- | -- | | -- | Chemical compounds | HeLa | -- | Cervical cancer | Accelerate | | L | 23807740 |
| Sen_E_498 | IS | -- | -- | | -- | Chemical compounds | MSC | -- | Aging | Accelerate | | L | 29734669 |
| Sen_E_499 | Ligusticum chuanxiong | -- | -- | | -- | Chemical compounds | HMSC | -- | Aging | Prevent | | L | 28040510 |
| Sen_E_500 | DHJST | -- | -- | | -- | Chemical compounds | HMSC | -- | Aging | Prevent | | L | 28040510 |
| Sen_E_501 | Co-EPM | -- | -- | | -- | Chemical compounds | HL60 | -- | Malignant mesothelioma | Accelerate | | L | 24057048 |
| Sen_E_502 | STR1720 | -- | -- | | -- | Chemical compounds | MDA-MB-231 | -- | Breast cancer | Prevent | | L | 29653746 |
| Sen_E_503 | EX527 | -- | -- | | -- | Chemical compounds | MDA-MB-231 | -- | Breast cancer | Accelerate | | L | 29653746 |
| Sen_E_504 | Homocysteine | -- | -- | | -- | Chemical compounds | HUVEC | -- | Aging | Accelerate | | L | 23336586 |
| Sen_E_505 | ROS | -- | -- | | -- | Chemical compounds | UCB-MSC | -- | Aging | Accelerate | | L | 22066510 |
| Sen_E_506 | Docosahexaenoic acid | -- | -- | | -- | Chemical compounds | RPE | -- | Aging | Accelerate | | L | 25108204 |
| Sen_E_507 | H2O2 | -- | -- | | -- | Chemical compounds | NIH-3T3 | -- | Aging | Accelerate | | L | 27791464 |
| Sen_E_508 | H2O2 | -- | -- | | -- | Chemical compounds | Chondrocyte | -- | Aging | Accelerate | | L | 21284033 |
| Sen_E_509 | PFG | -- | -- | | -- | Chemical compounds | TIG-1,HeLa | -- | Aging | Accelerate | | L | 30836860 |
| Sen_E_510 | H2O2 | -- | -- | | -- | Chemical compounds | MEF | -- | Aging | Accelerate | | L | 23623979 |
| Sen_E_511 | ROS | -- | -- | | -- | Chemical compounds | NPC | NP tissue | Aging | Accelerate | | L | 29890141 |
| Sen_E_512 | Trichostatin A | -- | -- | | -- | Chemical compounds | U87 | -- | Glioblastoma | Accelerate | | L | 24464841 |
| Sen_E_513 | JQ-101 | -- | -- | | -- | Chemical compounds | LNCaP,PC-3,H1299,A549 | -- | Cancer | Accelerate | | L | 25189993 |
| Sen_E_514 | H2O2 | -- | -- | | -- | Chemical compounds | HUVEC | -- | Aging | Accelerate | | L | 25038529 |
| Sen_E_515 | NO? | -- | -- | | -- | Chemical compounds | Fibroblast | -- | Colorectal cancer | Accelerate | | HL | 22970173 |
| Sen_E_516 | SAHA | -- | -- | | -- | Chemical compounds | MSC | -- | Aging | Prevent | | L | 18694296 |
| Sen_E_517 | MS-275 | -- | -- | | -- | Chemical compounds | MSC | -- | Aging | Accelerate | | L | 18694296 |
| Sen_E_518 | H2O2 | -- | -- | | -- | Chemical compounds | Chang | -- | Aging | Accelerate | | L | 16883569 |
| Sen_E_519 | N-Acetylcysteine | -- | -- | | -- | Chemical compounds | Endothelial cell | -- | Aging | Prevent | | L | 14963003 |
| Sen_E_520 | Atorvastatin | -- | -- | | -- | Chemical compounds | Endothelial cell | -- | Aging | Prevent | | L | 14963003 |
| Sen_E_521 | L2-Cmu | -- | -- | | -- | Chemical compounds | -- | Heart | Aging | Prevent | | L | 29921922 |
| Sen_E_522 | C-phycocyanin | -- | -- | | -- | Chemical compounds | -- | Kidney,Spleen,Ovary | Aging | Prevent | | L | 27008700 |
| Sen_E_523 | Quercetin | -- | -- | | -- | Chemical compounds | RPE | -- | Aging | Prevent | | L | 18385095 |
| Sen_E_524 | JQ1 | -- | -- | | -- | Chemical compounds | MKN28 | -- | Gastric cancer | Accelerate | | L | 29434197 |
| Sen_E_525 | Protease inhibitors | -- | -- | | -- | Chemical compounds | Fibroblast | -- | Lipodystrophic syndromes | Accelerate | | L | 17612587 |
| Sen_E_526 | Tenovin-6 | -- | -- | | -- | Chemical compounds | HF043 | -- | Aging | Accelerate | | L | 30666570 |
| Sen_E_527 | ATRA | -- | -- | | -- | Chemical compounds | NB4 | -- | Acute leukemia | Accelerate | | L | 25092303 |
| Sen_E_528 | Antioxidant | -- | -- | | -- | Chemical compounds | NIH-3T3 | -- | Aging | Prevent | | L | 12134086 |
| Sen_E_529 | Doxorubicin | -- | -- | | -- | Chemical compounds | MSC | -- | Aging | Accelerate | | L | 29207187 |
| Sen_E_530 | SB203580 | -- | -- | | -- | Chemical compounds | HCEC | -- | Aging | Prevent | | HL | 28672399 |
| Sen_E_531 | Bleomycin | -- | -- | | -- | Chemical compounds | HAEC | -- | Aging | Accelerate | | L | 27878894 |
| Sen_E_532 | Bleomycin | -- | -- | | -- | Chemical compounds | HUVEC | -- | Aging | Accelerate | | L | 28064010 |
| Sen_E_533 | Etoposide | -- | -- | | -- | Chemical compounds | HepG2,U2OS | -- | Liver cancer | Accelerate | | L | 24223226 |
| Sen_E_534 | Bleomycin | -- | -- | | -- | Chemical compounds | U2OS | -- | Liver cancer | Accelerate | | L | 24223226 |
| Sen_E_535 | NAC | -- | -- | | -- | Chemical compounds | A375,NIH-3T3 | -- | Aging | Prevent | | L | 30555576 |
| Sen_E_536 | Caffeine | -- | -- | | -- | Chemical compounds | A375,NIH-3T3 | -- | Aging | Prevent | | L | 30555576 |
| Sen_E_537 | Rapamycin | -- | -- | | -- | Chemical compounds | HCAEC | -- | Aging | Prevent | | L | 32164764 |
| Sen_E_538 | Bleomycin | -- | -- | | -- | Chemical compounds | HCA2 | -- | Aging | Accelerate | | L | 19805069 |
| Sen_E_539 | 4-hydroxytamoxifen | -- | -- | | -- | Chemical compounds | ALT | -- | Acute leukemia | Accelerate | | L | 19468068 |
| Sen_E_540 | Resveratrol | -- | -- | | -- | Chemical compounds | HCPC | -- | Heart failure | Prevent | | L | 25889431 |
| Sen_E_541 | Rapamycin | -- | -- | | -- | Chemical compounds | Fibroblast | -- | Dyskeratosis congenita | Prevent | | HL | 26546739 |
| Sen_E_542 | H2O2 | -- | -- | | -- | Chemical compounds | BM-MSC | -- | Aging | Accelerate | | L | 25975679 |
| Sen_E_543 | N-acetylcysteine | -- | -- | | -- | Chemical compounds | Keratinocyte | -- | Aging | Prevent | | HL | 31551408 |
| Sen_E_544 | Capecitabine | -- | -- | | -- | Chemical compounds | Endothelial cell | -- | Aging | Accelerate | | L | 28127745 |
| Sen_E_545 | Glucocorticoid | -- | -- | | -- | Chemical compounds | MSC | -- | Aging | Accelerate | | L | 23963647 |
| Sen_E_546 | C75 | -- | -- | | -- | Chemical compounds | HSC | -- | Aging | Prevent | | L | 30962418 |
| Sen_E_547 | Palmitic acid | -- | -- | | -- | Chemical compounds | HepG2 | -- | Aging | Accelerate | | L | 28868154 |
| Sen_E_548 | Everolimus | -- | -- | | -- | Chemical compounds | B220 | -- | Eμ-Myc lymphoma | Accelerate | | L | 23242809 |
| Sen_E_549 | Dehydroleucodine | -- | -- | | -- | Chemical compounds | HeLa,MCF-7 | -- | Melanoma | Accelerate | | L | 26718258 |
| Sen_E_550 | Paclitaxel | -- | -- | | -- | Chemical compounds | MKN45 | -- | Gastric cancer | Accelerate | | L | 25483095 |
| Sen_E_551 | Glutathione | -- | -- | | -- | Chemical compounds | HeLa | -- | Werner syndrome | Prevent | | L | 24757718 |
| Sen_E_552 | Furanoflavones pongapin | -- | -- | | -- | Chemical compounds | MCF-7-1A1 | -- | Breast cancer | Accelerate | | L | 30448188 |
| Sen_E_553 | Lanceolatin B | -- | -- | | -- | Chemical compounds | MCF-7-1A1 | -- | Breast cancer | Accelerate | | L | 30448188 |
| Sen_E_554 | Doxorubicin | -- | -- | | -- | Chemical compounds | A431 | -- | Squamous cell carcinoma | Accelerate | | HL | 21471201 |
| Sen_E_555 | Resveratrol | -- | -- | | -- | Chemical compounds | A431 | -- | Squamous cell carcinoma | Accelerate | | HL | 21471201 |
| Sen_E_556 | Doxorubicin | -- | -- | | -- | Chemical compounds | HepG2 | -- | Aging | Accelerate | | L | 31942817 |
| Sen_E_557 | SCIC2 | -- | -- | | -- | Chemical compounds | HepG2 | -- | Aging | Prevent | | L | 31942817 |
| Sen_E_558 | SCIC2.1 | -- | -- | | -- | Chemical compounds | HepG2 | -- | Aging | Prevent | | L | 31942817 |
| Sen_E_559 | Ang II | -- | -- | | -- | Chemical compounds | Glomerular mesangial cell | -- | Aging | Accelerate | | L | 30389500 |
| Sen_E_560 | Probucol | -- | -- | | -- | Chemical compounds | Glomerular mesangial cell | -- | Aging | Prevent | | L | 30389500 |
| Sen_E_561 | RG108 | -- | -- | | -- | Chemical compounds | pBM-MSC | Bone marrow | Aging | Prevent | | HL | 32125888 |
| Sen_E_562 | Estrogen | -- | -- | | -- | Chemical compounds | MSC,Chondrocyte | Bone marrow,Bone | Aging | Prevent | | L | 21469181 |
| Sen_E_563 | GlyH-101 | -- | -- | | -- | Chemical compounds | Erythrocyte | Blood | Beta Thalassemia | Prevent | | L | 23383265 |
| Sen_E_564 | Rapamycin | -- | -- | | -- | Chemical compounds | HDF | -- | Aging | Prevent | | L | 28067204 |
| Sen_E_565 | Adriamycin | -- | -- | | -- | Chemical compounds | MCF-7 | -- | Aging | Accelerate | | L | 17161377 |
| Sen_E_566 | Pan-mTOR inhibitors | -- | -- | | -- | Chemical compounds | MEL10,SK-BR-3 | -- | Aging | Prevent | | L | 28077803 |
| Sen_E_567 | MLN4924 | -- | -- | | -- | Chemical compounds | PC-3 | -- | Prostate cancer | Accelerate | | L | 20237562 |
| Sen_E_568 | WS-CoQ10 | -- | -- | | -- | Chemical compounds | PSAF | -- | Alzheimer's disease | Prevent | | L | 25034304 |
| Sen_E_569 | Apocynin | -- | -- | | -- | Chemical compounds | Endothelial cell | -- | Aging | Prevent | | L | 26672612 |
| Sen_E_570 | Indomethacin | -- | -- | | -- | Chemical compounds | Endothelial cell | -- | Aging | Prevent | | L | 26672612 |
| Sen_E_571 | VAS-2870 | -- | -- | | -- | Chemical compounds | Endothelial cell | -- | Aging | Prevent | | L | 26672612 |
| Sen_E_572 | Salvia haenkei | -- | -- | | -- | Chemical compounds | Fibroblast | -- | Aging | Prevent | | L | 27922821 |
| Sen_E_573 | Linoleic acid | -- | -- | | -- | Chemical compounds | HAEC | -- | Aging | Accelerate | | L | 26051603 |
| Sen_E_574 | H2O2 | -- | -- | | -- | Chemical compounds | MRC-5 | -- | Aging | Accelerate | | L | 24238886 |
| Sen_E_575 | TBHP | -- | -- | | -- | Chemical compounds | HUVEC | -- | Aging | Accelerate | | L | 22563892 |
| Sen_E_576 | H2O2 | -- | -- | | -- | Chemical compounds | Erythrocyte | Blood | Beta Thalassemia | Accelerate | | L | 23383265 |
| Sen_E_577 | 5-Fu | -- | -- | | -- | Chemical compounds | SMMC?7721 | -- | Hepatocellular carcinoma | Accelerate | | L | 18075305 |
| Sen_E_578 | R1530 | -- | -- | | -- | Chemical compounds | H460,HCT116 | -- | Cancer | Accelerate | | L | 20814247 |
| Sen_E_579 | Ginsenoside Rh2 | -- | -- | | -- | Chemical compounds | MDA-MB-231,MCF 10A | -- | Breast cancer | Prevent | | HL | 30871042 |
| Sen_E_580 | Doxorubicin | -- | -- | | -- | Chemical compounds | MDA-MB-231,MCF 10A | -- | Breast cancer | Accelerate | | HL | 30871042 |
| Sen_E_581 | Doxorubicin | -- | -- | | -- | Chemical compounds | SW982,NHDF,FU-SY-1 | -- | Synovial sarcoma | Accelerate | | HL | 16705698 |
| Sen_E_582 | Rapamycin | -- | -- | | -- | Chemical compounds | HCEC | Cornea | Aging | Prevent | | L | 28054657 |
| Sen_E_583 | Berberine | -- | -- | | -- | Chemical compounds | A549 | -- | Lung cancer | Accelerate | | L | 31978448 |
| Sen_E_584 | PTX | -- | -- | | -- | Chemical compounds | HeLa,SiHa,HaCaT | -- | Cervical cancer | Prevent | | L | 22074157 |
| Sen_E_585 | PTX | -- | -- | | -- | Chemical compounds | HeLa,SiHa,HaCaT | -- | Cervical cancer | Prevent | | L | 20482878 |
| Sen_E_586 | Vemurafenib | -- | -- | | -- | Chemical compounds | M14,Malme 3M,SK-MEL-28,UACC-62 | -- | Melanoma | Accelerate | | L | 23321925 |
| Sen_E_587 | Cisplatin | -- | -- | | -- | Chemical compounds | SUNEl,HT29 | -- | Cancer | Accelerate | | L | 10568814 |
| Sen_E_588 | UDCA | -- | -- | | -- | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | HL | 17019713 |
| Sen_E_589 | ATO | -- | -- | | -- | Chemical compounds | MSC | Blood | Aging | Accelerate | | L | 21257625 |
| Sen_E_590 | Rapamycin | -- | -- | | -- | Chemical compounds | PBMC | -- | Lymphatic filariasis | Prevent | | L | 25849993 |
| Sen_E_591 | 3-methyladenine | -- | -- | | -- | Chemical compounds | B-MSC | -- | Aging | Prevent | | L | 25961745 |
| Sen_E_592 | N-acetylcysteine | -- | -- | | -- | Chemical compounds | B-MSC | -- | Aging | Prevent | | L | 25961745 |
| Sen_E_593 | DPI | -- | -- | | -- | Chemical compounds | B-MSC | -- | Aging | Prevent | | L | 25961745 |
| Sen_E_594 | Antimitotic drugs | -- | -- | | -- | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | HL | 30037855 |
| Sen_E_595 | Malvidin | -- | -- | | -- | Chemical compounds | Chondrocyte | Bone | Osteoarthritis | Prevent | | L | 28852776 |
| Sen_E_596 | Tetra-Pt | -- | -- | | -- | Chemical compounds | Saos-2 | -- | Cancer | Accelerate | | HL | 28521363 |
| Sen_E_597 | 4SC-202 | -- | -- | | -- | Chemical compounds | HEK293T,UM-UC-3,VM-CUB1,HBLAK | -- | Urothelial Carcinoma | Accelerate | | L | 27250763 |
| Sen_E_598 | 19i | -- | -- | | -- | Chemical compounds | HEK293,UM-UC-3,VM-CUB1,HBLAK | -- | Urothelial carcinoma | Accelerate | | L | 30064501 |
| Sen_E_599 | RSC96 Schwann cell-derived exosomes | -- | -- | | -- | Chemical compounds | DRG,RSC96 | -- | Aging | Prevent | | L | 30387453 |
| Sen_E_600 | Antroquinonol | -- | -- | | -- | Chemical compounds | AsPC-1 | -- | Pancreatic cancer | Accelerate | | L | 21840189 |
| Sen_E_601 | Resveratrol | -- | -- | | -- | Chemical compounds | HPMC | -- | Aging | Prevent | | L | 22579575 |
| Sen_E_602 | MLN4924 | -- | -- | | -- | Chemical compounds | SJSA-1,MG-63 | -- | Osteosarcoma | Accelerate | | HL | 27223074 |
| Sen_E_603 | EGCG | -- | -- | | -- | Chemical compounds | NB4,K562 | -- | Myeloid leukemia | Accelerate | | L | 30194939 |
| Sen_E_604 | Hinokitiol | -- | -- | | -- | Chemical compounds | A549,H1975,H1299,H3255,PC-9,PC-9-IR | Tumor tissue | Lung cancer | Accelerate | | HL | 25105411 |
| Sen_E_605 | C-1311 | -- | -- | | -- | Chemical compounds | HepG2 | -- | Hepatocellular carcinoma | Accelerate | | L | 23319370 |
| Sen_E_606 | Disorazole C1 | -- | -- | | -- | Chemical compounds | HCT116,H1299,UPCI:SCC103 | -- | Cancer | Accelerate | | HL | 19066338 |
| Sen_E_607 | A83-01 | -- | -- | | -- | Chemical compounds | eMSC | -- | Aging | Prevent | | L | 26461813 |
| Sen_E_608 | Chloramphenicol | -- | -- | | -- | Chemical compounds | H1299 | -- | Aging | Accelerate | | L | 15905168 |
| Sen_E_609 | MTX | -- | -- | | -- | Chemical compounds | Melanoma cell | -- | Melanoma | Accelerate | | HL | 24862567 |
| Sen_E_610 | Etoposide | -- | -- | | -- | Chemical compounds | A549 | -- | Lung cancer | Accelerate | | L | 21924246 |
| Sen_E_611 | F14512 | -- | -- | | -- | Chemical compounds | A549 | -- | Lung cancer | Accelerate | | L | 21924246 |
| Sen_E_612 | Erlotinib | -- | -- | | -- | Chemical compounds | Epithelial cell | Cervical | Cervical cancer | Accelerate | | L | 21982220 |
| Sen_E_613 | Gemcitabine | -- | -- | | -- | Chemical compounds | PANC-1 | -- | Pancreatic cancer | Accelerate | | L | 25843411 |
| Sen_E_614 | EX527 | -- | -- | | -- | Chemical compounds | PANC-1 | -- | Pancreatic cancer | Accelerate | | L | 25843411 |
| Sen_E_615 | H2O2 | -- | -- | | -- | Chemical compounds | ARPE?19 | -- | Aging | Accelerate | | L | 26044821 |
| Sen_E_616 | Lidamycin | -- | -- | | -- | Chemical compounds | BEL-7402 | -- | Liver cancer | Accelerate | | L | 15309709 |
| Sen_E_617 | BET inhibitor JQ1 | -- | -- | | -- | Chemical compounds | MyLa,SeAx,HuT 78,HH | -- | T-cell lymphoma | Accelerate | | L | 28593508 |
| Sen_E_618 | Bleomycin | -- | -- | | -- | Chemical compounds | Fibroblast | Lung | Idiopathic pulmonary fibrosis | Accelerate | | L | 27979858 |
| Sen_E_619 | OX-LDL | -- | -- | | -- | Chemical compounds | HBMEC | -- | Aging | Accelerate | | L | 27903586 |
| Sen_E_620 | Resveratrol | -- | -- | | -- | Chemical compounds | U87 MG | -- | Glioma | Accelerate | | L | 25875864 |
| Sen_E_621 | Metformin | -- | -- | | -- | Chemical compounds | MDA-MB-468 | -- | Breast cancer | Accelerate | | HL | 23395946 |
| Sen_E_622 | Metformin | -- | -- | | -- | Chemical compounds | -- | Tumor tissue | Squamous cell carcinoma | Accelerate | | L | 28185288 |
| Sen_E_623 | 4-hydroxynonenal | -- | -- | | -- | Chemical compounds | ARPE?19 | -- | Retinal damage | Accelerate | | L | 31070214 |
| Sen_E_624 | Cyanidin-3-glucoside | -- | -- | | -- | Chemical compounds | ARPE?19 | -- | Retinal damage | Prevent | | L | 31070214 |
| Sen_E_625 | Paclitaxel | -- | -- | | -- | Chemical compounds | MSC1,MSC2,Hs68,Dermal Fibroblast,MRC-5 | Bone marrow | Aging | Accelerate | | L | 29321693 |
| Sen_E_626 | Imatinib(IM) | -- | -- | | -- | Chemical compounds | Primary tumor cell | Tumor tissue | Fibrosarcoma | Accelerate | | HL | 27608549 |
| Sen_E_627 | Cisplatin | -- | -- | | -- | Chemical compounds | MSC | -- | Breast cancer | Accelerate | | HL | 26759169 |
| Sen_E_628 | Pochoxime-derived inhibitor NW457 | -- | -- | | -- | Chemical compounds | HT-1080 | -- | Soft tissue sarcomas | Accelerate | | HL | 26044951 |
| Sen_E_629 | Y-27632 | -- | -- | | -- | Chemical compounds | HDPDC | Odontoma | Odontomas | Prevent | | L | 27514999 |
| Sen_E_630 | Cisplatin | -- | -- | | -- | Chemical compounds | A549 | -- | Lung cancer | Accelerate | | L | 26895954 |
| Sen_E_631 | MTA | -- | -- | | -- | Chemical compounds | A549 | -- | Lung cancer | Accelerate | | L | 26895954 |
| Sen_E_632 | JQ1 | -- | -- | | -- | Chemical compounds | G-292,MG-63,MNNG/HOS,SJSA | -- | Osteosarcoma | Accelerate | | HL | 25307878 |
| Sen_E_633 | Tamoxifen | -- | -- | | -- | Chemical compounds | GBM3,GBM6,GBM11 | -- | Glioma | Accelerate | | HL | 29991800 |
| Sen_E_634 | LY2801653 | -- | -- | | -- | Chemical compounds | TFK-1,SZ-1 | -- | Cholangiocarcinoma | Accelerate | | HL | 26757360 |
| Sen_E_635 | DMSO | -- | -- | | -- | Chemical compounds | TFK-1,SZ-1 | -- | Cholangiocarcinoma | Accelerate | | HL | 26757360 |
| Sen_E_636 | AZD2014 | -- | -- | | -- | Chemical compounds | DIPG 4,SF7761 | Tumor tissue | Diffuse intrinsic pontine glioma | Accelerate | | HL | 29207163 |
| Sen_E_637 | Everolimus | -- | -- | | -- | Chemical compounds | DIPG 4,SF7761 | Tumor tissue | Diffuse intrinsic pontine glioma | Accelerate | | HL | 29207163 |
| Sen_E_638 | Cyclosporine A | -- | -- | | -- | Chemical compounds | T98G,U373 MG,U87 MG | -- | Glioma | Accelerate | | L | 16087277 |
| Sen_E_639 | MLN8237 | -- | -- | | -- | Chemical compounds | GIST882,GIST48,GIST430 | -- | Gastrointestinal stromal tumor | Accelerate | | L | 24901229 |
| Sen_E_640 | MLN4924 | -- | -- | | -- | Chemical compounds | GBM,U251,A172 | -- | Glioblastoma | Accelerate | | L | 25904638 |
| Sen_E_641 | Idebenone | -- | -- | | -- | Chemical compounds | Human lamina cribrosa Astrocyte | Eye | Glaucoma | Prevent | | L | 23661043 |
| Sen_E_642 | Temozolomide | -- | -- | | -- | Chemical compounds | LN-229,A172,U87 MG | -- | Glioblastoma | Accelerate | | L | 27626497 |
| Sen_E_643 | Artesunate | -- | -- | | -- | Chemical compounds | LN-229,A172,U87 MG | -- | Glioblastoma | Prevent | | L | 27626497 |
| Sen_E_644 | Adriamycin | -- | -- | | -- | Chemical compounds | HT-1080 | -- | Aging | Accelerate | | L | 16204065 |
| Sen_E_645 | U0126 | -- | -- | | -- | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | L | 24136223 |
| Sen_E_646 | Tamoxifen | -- | -- | | -- | Chemical compounds | HUVEC | -- | Aging | Accelerate | | L | 18203850 |
| Sen_E_647 | 3-methyladenine | -- | -- | | -- | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 18203850 |
| Sen_E_648 | STI571 | -- | -- | | -- | Chemical compounds | K562 | -- | Chronic myeloid leukemia | Prevent | | L | 18281522 |
| Sen_E_649 | BETi+ATRi | -- | -- | | -- | Chemical compounds | λ820 | -- | Lymphoma | Accelerate | | HL | 26804177 |
| Sen_E_650 | Bleomycin | -- | -- | | -- | Chemical compounds | -- | Lung | Idiopathic pulmonary fibrosis | Accelerate | | HL | 29133960 |
| Sen_E_651 | Lidamycin | -- | -- | | -- | Chemical compounds | MCF-7 | -- | Breast cancer | Accelerate | | L | 19725468 |
| Sen_E_652 | CHCl3:Me-OH | -- | -- | | -- | Chemical compounds | HDF | -- | Aging | Accelerate | | L | 26161621 |
| Sen_E_653 | PCO-rHDL | -- | -- | | -- | Chemical compounds | HDF | -- | Aging | Prevent | | L | 26161621 |
| Sen_E_654 | Valproic acid | -- | -- | | -- | Chemical compounds | DU 145,PC-3 | -- | Prostate cancer | Accelerate | | L | 17477369 |
| Sen_E_655 | Midostaurin | -- | -- | | -- | Chemical compounds | KRAS-mutant cell | -- | Lung cancer | Accelerate | | HL | 25667133 |
| Sen_E_656 | Convallatoxin | -- | -- | | -- | Chemical compounds | NSCLC,A549 | -- | Lung cancer | Accelerate | | L | 28176244 |
| Sen_E_657 | Curcumin | -- | -- | | -- | Chemical compounds | HROC257 T0 M1,HROC50 T1 M5,HROC60,HROC183 T0 M2 | -- | Colorectal cancer | Accelerate | | L | 30891459 |
| Sen_E_658 | MLN4924 | -- | -- | | -- | Chemical compounds | 786-O,ACNH | -- | Renal carcinoma | Accelerate | | L | 29667067 |
| Sen_E_659 | Etoposide | -- | -- | | -- | Chemical compounds | IMR-90 | -- | Aging | Accelerate | | HL | 28607003 |
| Sen_E_660 | Rapamycin | -- | -- | | -- | Chemical compounds | PBMC | Blood | Lymphatic filariasis | Prevent | | L | 25849993 |
| Sen_E_661 | MLN4924 | -- | -- | | -- | Chemical compounds | A549,H460,H1299 | -- | Lung?cancer | Accelerate | | HL | 24853380 |
| Sen_E_662 | Metformin | -- | -- | | -- | Chemical compounds | HN 30,HN 31 | -- | Squamous cell carcinoma | Accelerate | | L | 22090360 |
| Sen_E_663 | TBHP | -- | -- | | -- | Chemical compounds | Primary mice Chondrocyte,Primary human Chondrocyte | -- | Osteoarthritis | Accelerate | | L | 30154423 |
| Sen_E_664 | SN-38 | -- | -- | | -- | Chemical compounds | HCT116 | -- | Colorectal cancer | Accelerate | | L | 15374978 |
| Sen_E_665 | LPD | -- | -- | | -- | Chemical compounds | SMMC-7721,HepG2 | -- | Hepatocellular carcinoma | Accelerate | | L | 24060417 |
| Sen_E_666 | Trabectedin | -- | -- | | -- | Chemical compounds | U2OS,SW872 | -- | Sarcoma | Accelerate | | L | 26933761 |
| Sen_E_667 | Hyaluronan | -- | -- | | -- | Chemical compounds | MSC | Bone marrow | Aging | Prevent | | L | 30001217 |
| Sen_E_668 | H2O2 | -- | -- | | -- | Chemical compounds | SRA01/04 | -- | Age-related cataract | Accelerate | | L | 22043305 |
| Sen_E_669 | H2O2 | -- | -- | | -- | Chemical compounds | WI-38 | -- | Aging | Accelerate | | L | 28120917 |
| Sen_E_670 | Antioxidant | -- | -- | | -- | Chemical compounds | CdLS 417,CdLS 565 | -- | Cornelia de Lange syndrome | Prevent | | HL | 29860495 |
| Sen_E_671 | Cyclin-dependent kinase inhibitors | -- | -- | | -- | Chemical compounds | TIG-3 | -- | Aging | Accelerate | Others | L | 9512419 |
| Sen_E_672 | Caloric restriction | -- | -- | | -- | Other | White blood cell | Bone | Aging | Prevent | | L | 23349740 |
| Sen_E_673 | Stress recovery | -- | -- | | -- | Other | MCAS,HEC-1 | -- | Aging | Accelerate | | HL | 30109767 |
| Sen_E_674 | Irradiation | -- | -- | | -- | Other | MEF | -- | Aging | Accelerate | | L | 29579719 |
| Sen_E_675 | Ionizing radiation | -- | -- | | -- | Other | MCF-7 | -- | Aging | Accelerate | | HL | 26717900 |
| Sen_E_676 | Ionizing radiation | -- | -- | | -- | Other | MRC-5 | -- | Aging | Accelerate | | L | 20160708 |
| Sen_E_677 | Cigarette smoke | -- | -- | | -- | Other | A549 | Lung | Aging | Accelerate | | L | 15333326 |
| Sen_E_678 | Human respiratory syncytial virus | -- | -- | | -- | Other | HEp-2,A549 | Lung | Aging | Accelerate | | L | 26809688 |
| Sen_E_679 | Garcinol | -- | -- | | -- | Other | A549 | -- | Lung cancer | Accelerate | | L | 22417805 |
| Sen_E_680 | Irradiation | -- | -- | | -- | Other | A549,H1299 | -- | Aging | Accelerate | | L | 27341700 |
| Sen_E_681 | Cigarette smoke extract | -- | -- | | -- | Other | ARPE?19 | -- | Aging | Accelerate | | L | 28767736 |
| Sen_E_682 | Smoking | -- | -- | | -- | Other | HDF | Blood,Embryo | Aging | Accelerate | | L | 24798380 |
| Sen_E_683 | CrVI | -- | -- | | -- | Other | Fibroblast,WI-38 | Blood | Aging | Accelerate | | L | 15236767 |
| Sen_E_684 | Platinum(II)phenanthroimidazole G-quadruplex ligand | -- | -- | | -- | Other | A549,HuH-7,MRC-5 | -- | Cancer | Accelerate | | L | 26724375 |
| Sen_E_685 | Chronic hypoxic conditioning | -- | -- | | -- | Other | PwR-1E | -- | Aging | Accelerate | | L | 19584087 |
| Sen_E_686 | Lonizing irradiation | -- | -- | | -- | Other | U2OS,MCF-7 | -- | Aging | Accelerate | | L | 27760841 |
| Sen_E_687 | COPD | -- | -- | | -- | Other | Promo Cell | -- | Chronic?obstructive?pulmonary?disease | Accelerate | | L | 30154415 |
| Sen_E_688 | NES-hTERT | -- | -- | | -- | Other | GM847 | -- | Aging | Accelerate | | L | 20089117 |
| Sen_E_689 | Chromosome 5 | -- | -- | | -- | Other | A2058 | -- | Melanoma | Accelerate | | L | 20621064 |
| Sen_E_690 | UVB | -- | -- | | -- | Other | Fibroblast | Skin | Aging | Accelerate | | L | 25165029 |
| Sen_E_691 | Lipogenesis | -- | -- | | -- | Other | Chang | -- | Aging | Accelerate | | L | 20615871 |
| Sen_E_692 | Pressure | -- | -- | | -- | Other | Fibroblast | -- | Aging | Accelerate | | L | 15734488 |
| Sen_E_693 | UVB | -- | -- | | -- | Other | NIH-3T3 | -- | Aging | Accelerate | | L | 23804320 |
| Sen_E_694 | Radiation | -- | -- | | -- | Other | HNSCC,FaDu-DN,FaDu-EBV,FaDu-HE | -- | Squamous cell carcinoma | Accelerate | | L | 26635065 |
| Sen_E_695 | Gamma irradiation | -- | -- | | -- | Other | MRC-5,HFF | -- | Aging | Accelerate | | HL | 27464526 |
| Sen_E_696 | UVB | -- | -- | | -- | Other | Keratinocyte | -- | Aging | Accelerate | | L | 22335598 |
| Sen_E_697 | X-irradiation | -- | -- | | -- | Other | A549 | -- | Chronic obstructive pulmonary disease | Accelerate | | L | 22267761 |
| Sen_E_698 | High glucose | -- | -- | | -- | Other | HMSC | -- | Aging | Accelerate | | L | 31089945 |
| Sen_E_699 | γ-irradiation | -- | -- | | -- | Other | A172,HCT116,MCF-7,U2OS,U87 | -- | Aging | Accelerate | | L | 19648966 |
| Sen_E_700 | X-irradiation | -- | -- | | -- | Other | Endothelial cell | -- | Chronic obstructive pulmonary disease | Accelerate | | L | 22267761 |
| Sen_E_701 | Autophagy | -- | -- | | -- | Other | BEC | -- | Primary biliary cirrhosis | Accelerate | | L | 20212459 |
| Sen_E_702 | UV | -- | -- | | -- | Other | NIH-3T3 | -- | Aging | Accelerate | | L | 12134086 |
| Sen_E_703 | High glucose | -- | -- | | -- | Other | Endothelial cell | -- | Type 2 diabetes mellitus | Accelerate | | L | 27101740 |
| Sen_E_704 | Serum starvation | -- | -- | | -- | Other | WI-38 | -- | Aging | Accelerate | | L | 31931659 |
| Sen_E_705 | X-ray | -- | -- | | -- | Other | HPAEC | -- | Aging | Accelerate | | HL | 24205274 |
| Sen_E_706 | Homologous recombination | -- | -- | | -- | Other | OE33 | -- | Esophageal cancer | Prevent | | HL | 23604115 |
| Sen_E_707 | Ionizing radiation | -- | -- | | -- | Other | MCF-7 | -- | Aging | Accelerate | | L | 25801233 |
| Sen_E_708 | Elovanoids | -- | -- | | -- | Other | RPE | -- | Aging | Prevent | | HL | 31712409 |
| Sen_E_709 | Nano-hydroxyapatite/chitosan/poly lactide-co-glycolide | -- | -- | | -- | Other | HUCMSC | -- | Aging | Prevent | | L | 32323459 |
| Sen_E_710 | Radiation | -- | -- | | -- | Other | T47D | -- | Breast cancer | Accelerate | | L | 20158881 |
| Sen_E_711 | Garlic | -- | -- | | -- | Other | HaCaT | -- | Aging | Prevent | | L | 27483310 |
| Sen_E_712 | Fibroblast-Derived Extracellular Matrix | -- | -- | | -- | Other | ad-MSC | Adipose | Aging | Prevent | | L | 27527147 |
| Sen_E_713 | Brown alga Undaria pinnatifida | -- | -- | | -- | Other | BM-MSC | -- | Aging | Prevent | | L | 30460058 |
| Sen_E_714 | Gamma-tocotrienol | -- | -- | | -- | Other | HDF | Foreskin | Aging | Prevent | | L | 22358238 |
| Sen_E_715 | UV irradiation | -- | -- | | -- | Other | -- | Skin | Aging | Accelerate | | L | 23881607 |
| Sen_E_716 | HIV infection | -- | -- | | -- | Other | CD4 peripheral T-cell | Blood | AIDS | Accelerate | | L | 22735071 |
| Sen_E_717 | CD9-Lac/CaCO3/Rapa | -- | -- | | -- | Other | HDF | -- | Aging | Prevent | | L | 28393891 |
| Sen_E_718 | Hp | -- | -- | | -- | Other | HDF | Foreskin | Aging | Accelerate | | L | 17924880 |
| Sen_E_719 | Sulfur mustard | -- | -- | | -- | Other | MSC | Bone marrow | Chronic wound healing | Accelerate | | L | 28818580 |
| Sen_E_720 | Gamma irradiation | -- | -- | | -- | Other | Prostate epithelial cell | Prostate | Prostate cancer | Accelerate | | HL | 26590118 |
| Sen_E_721 | High glucose | -- | -- | | -- | Other | B-MSC | -- | Aging | Accelerate | | L | 25961745 |
| Sen_E_722 | Fc-OH-TAM | -- | -- | | -- | Other | Breast cancer cell | -- | Breast cancer | Accelerate | | L | 20116857 |
| Sen_E_723 | OH-TAM | -- | -- | | -- | Other | Breast cancer cell | -- | Breast cancer | Accelerate | | L | 20116857 |
| Sen_E_724 | Zn | -- | -- | | -- | Other | HCAEC | -- | Aging | Accelerate | | HL | 28918363 |
| Sen_E_725 | Alpha particles | -- | -- | | -- | Other | MSC | Bone marrow | Aging | Accelerate | | L | 28252222 |
| Sen_E_726 | Hypoxia | -- | -- | | -- | Other | Human Cardiac Progenitor Cell | Heart left ventricle | Mitochondrial Dysfunction | Prevent | | HL | 30629785 |
| Sen_E_727 | Mitochondrial ROS | -- | -- | | -- | Other | Human Cardiac Progenitor Cell | Heart left ventricle | Mitochondrial Dysfunction | Accelerate | | HL | 30629785 |
| Sen_E_728 | Radiation | -- | -- | | -- | Other | UMSCC1 | -- | Squamous cell carcinoma | Accelerate | | L | 22090360 |
| Sen_E_729 | Radiation | -- | -- | | -- | Other | MSC | Bone marrow | Aging | Accelerate | | L | 25544750 |
| Sen_E_730 | Hyperbaric air | -- | -- | | -- | Other | HDF | -- | Aging | Accelerate | | HL | 18465208 |
| Sen_E_731 | Normobaric mild hyperoxia | -- | -- | | -- | Other | HDF | -- | Aging | Accelerate | | HL | 18465208 |
| Sen_E_732 | Heat | -- | -- | | -- | Other | HUVEC | -- | Aging | Accelerate | | L | 25142166 |
| Sen_E_733 | SP600125+IR | -- | -- | | -- | Other | ARO,KTC-2 | -- | Anaplastic thyroid cancer | Accelerate | | L | 16571083 |
| Sen_E_734 | Hypoxia | -- | -- | | -- | Other | HPDC | Bone | Aging | Prevent | | L | 29082591 |
| Sen_E_735 | Ionizing radiation | -- | -- | | -- | Other | A549,H460,H1299 | -- | Lung cancer | Accelerate | | L | 26943034 |
| Sen_E_736 | 6 Gy irradiation | -- | -- | | -- | Other | 22RV1 | -- | Prostate cancer | Accelerate | | L | 17914094 |
| Sen_E_737 | Hyperthermia | -- | -- | | -- | Other | U2OS,SW872 | -- | Sarcoma | Accelerate | | L | 26933761 |
| Sen_E_738 | Gli1 PEI–SNAs | -- | -- | | -- | Other | U87 MG | -- | Glioblastoma | Accelerate | | L | 30260647 |
| Sen_E_739 | Radiation | -- | -- | | -- | Other | K562 | -- | Chronic myeloid leukemia | Accelerate | | L | 18281522 |
| Sen_E_740 | Radiation | -- | -- | | -- | Other | NT2/D1 | -- | Aging | Accelerate | | L | 31509479 |
| Sen_E_741 | Ionizing radiation | -- | -- | | -- | Other | DLD1 (KRAS wt/mut),DWT7 (wt/-) | -- | Lung cancer | Accelerate | | L | 24648348 |
| Sen_E_742 | UVA | -- | -- | | -- | Other | PrEC | -- | Aging | Accelerate | | L | 19651821 |
| Sen_E_743 | UVB | -- | -- | | -- | Other | Keratinocyte | -- | Aging | Accelerate | | HL | 31755176 |
| Sen_E_744 | Resveratrol | β-CATENIN | Downregulation | | Downregulation | Chemical compounds | MSC | Bone marrow | Aging | Prevent | | L | 26456654 |
| Sen_E_745 | Acrolein | WRN | Downregulation | | Activation | Chemical compounds | HFL-1 | -- | Aging | Accelerate | | L | 24747221 |
| Sen_E_746 | CO | MIR-34A | Downregulation | | Downregulation | Chemical compounds | WI-38 | -- | Aging | Prevent | | L | 32228197 |
| Sen_E_747 | 17β-E2 | SIRT3 | Upregulation | | -- | Chemical compounds | HUVECs | -- | Aging | Prevent | | L | 32172411 |
| Sen_E_748 | Aesculus | -- | -- | | Downregulation | Chemical compounds | hADMSCs | -- | Aging | Prevent | | L | 34679084 |
| Sen_E_749 | MATN3 | TGF-β | Upregulation | | -- | Chemical compounds | NPCs | -- | Intervertebral disc degeneration | Prevent | | L | 34136064 |
| Sen_E_750 | Maltol | -- | -- | | Activation//Activation | Chemical compounds | HEK293 | -- | Aging | Prevent | | L | 34028092 |
| Sen_E_751 | High glucose | -- | -- | | Downregulation | Chemical compounds | Chondrocyte | -- | Osteoarthritis | Accelerate | | L | 34006821 |
| Sen_E_752 | BBR | MIR-17-5P | Upregulation | | Downregulation | Chemical compounds | T24 cells,5637cells,253J cells | -- | Bladder cancer | Accelerate | | L | 33887260 |
| Sen_E_753 | PTX | -- | -- | | -- | Chemical compounds | PC3 cells | -- | Prostate cancer | Prevent | | L | 33711972 |
| Sen_E_754 | GMPS | -- | -- | | -- | Chemical compounds | HeLa cells,SiHa cells | -- | Cervical cancer | Accelerate | | L | 33649833 |
| Sen_E_755 | 5-AZA-Dc | MGAT5//ST3GAL4 | Upregulation//Upregulation | | -- | Chemical compounds | Breast cancer cells,ovarian cancer cells | -- | Aging | Accelerate | | HL | 33579350 |
| Sen_E_756 | EGT | HSP70 | Upregulation | | Activation | Chemical compounds | Keratinocytes,fibroblasts | -- | Photoaging | Prevent | | L | 33577831 |
| Sen_E_757 | IR | H2A.J | Upregulation | | Activation | Other | CD4+T | -- | Aging | Accelerate | | L | 31689464 |
| Sen_E_758 | CPBMF65 | -- | -- | | -- | Chemical compounds | HepG2,PBMC | -- | HCC | Accelerate | | L | 32367200 |
| Sen_E_759 | Hypoxia | -- | -- | | Activation | Other | -- | Synovial tissue | Osteoarthritis | Accelerate | | L | 32377698 |
| Sen_E_760 | Reoxygenation | -- | -- | | Activation | Other | -- | Synovial tissue | Osteoarthritis | Accelerate | | L | 32377699 |
| Sen_E_761 | NPs | -- | -- | | -- | Chemical compounds | IMR-90 | -- | Aging | Prevent | | L | 32400008 |
| Sen_E_762 | ABT-263 | -- | -- | | -- | Chemical compounds | SK-BR-7,U2OS,A549,HCC712,MDA-MB-175,MCF-7 | -- | Aging | Prevent | | L | 32457483 |
| Sen_E_763 | SFN | -- | -- | | -- | Chemical compounds | TE-1,ECA-109,HEEpiC | -- | Esophageal cancer | Accelerate | | HL | 32476238 |
| Sen_E_764 | Exosome | MIRNA-136 | Upregulation | | -- | Chemical compounds | UMSC,OMSC | -- | Aging | Prevent | | L | 32641103 |
| Sen_E_765 | ABT-263 | -- | -- | | Downregulation | Chemical compounds | NCI-A549,MDA-MB-231 | -- | Tumor | Prevent | | L | 32652830 |
| Sen_E_766 | PTE | -- | -- | | -- | Chemical compounds | PC-12,A375,H9C2 | -- | Aging | Accelerate | | L | 32659678 |
| Sen_E_767 | PTE | SIRT1//FOXO3A//BCL-2//AROS//HUR//BAX//P53//DBC1 | Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Downregulation//Downregulation//Downregulation | | -- | Chemical compounds | PC-12,A375,H9C2 | -- | Aging | Prevent | | L | 32659678 |
| Sen_E_768 | Wogonin | TXNRD2 | Downregulation | | -- | Chemical compounds | MDA-MB-231 | -- | TNBC | Accelerate | | HL | 32671444 |
| Sen_E_769 | TBHP | -- | -- | | Upregulation | Chemical compounds | HFF-1 | -- | Aging | Accelerate | | HL | 32710895 |
| Sen_E_770 | UA | -- | -- | | -- | Chemical compounds | HLE-B3 | -- | Cateract | Accelerate | | L | 32713071 |
| Sen_E_771 | Resveratrol | SIRT1 | Upregulation | | Downregulation | Chemical compounds | INS-1 | -- | Aging | Prevent | | L | 33326842 |
| Sen_E_772 | Osalmid | -- | -- | | -- | Chemical compounds | KYSE150 | -- | Esophageal cancer | Accelerate | | L | 32763454 |
| Sen_E_773 | AgNP | COX2 | Upregulation | | Upregulation | Chemical compounds | MRC5 | Lung | Aging | Accelerate | | HL | 32763567 |
| Sen_E_774 | TEF | -- | -- | | -- | Chemical compounds | PC-3 | -- | Prostate cancer | Accelerate | | L | 32768881 |
| Sen_E_775 | TSG | SIRT1 | Upregulation | | -- | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 32898442 |
| Sen_E_776 | Hinokitiol | CYCLIN D1//CYCLIN E | Downregulation//Downregulation | | Activation | Chemical compounds | HeLa | -- | Cervical cancer | Accelerate | | L | 32917321 |
| Sen_E_777 | 6,4′-Dihydroxy-7-methoxyflavanone | SIRT1 | Upregulation | | Downregulation | Chemical compounds | Human dermal fibroblasts | -- | Aging | Prevent | | L | 33111210 |
| Sen_E_778 | HIV infection | ATM | Downregulation | | Downregulation | Other | SupT1 | -- | HIV | Accelerate | | L | 32907975 |
| Sen_E_779 | JQ1 | BRD4 | Downregulation | | -- | Chemical compounds | KYSE450 | -- | Oesophageal cancer | Prevent | | L | 32954665 |
| Sen_E_780 | GSC | -- | -- | | -- | Chemical compounds | HAEC | -- | Aging | Prevent | | L | 32963699 |
| Sen_E_781 | Icariin (ICA) | -- | -- | | Upregulation | Chemical compounds | fibroblast | -- | Aging | Prevent | | L | 33000191 |
| Sen_E_782 | HIV | P24 | Upregulation | | Downregulation | Other | SupT1 | -- | AIDS | Accelerate | | L | 32907975 |
| Sen_E_783 | Trans-anethole | -- | -- | | -- | Chemical compounds | HepG2 | -- | Non-alcoholic fatty liver disease | Prevent | | L | 33114589 |
| Sen_E_784 | Benzo[a]pyrene | P21 | Upregulation | | Downregulation | Chemical compounds | MCF7 | -- | Aging | Accelerate | | L | 33166399 |
| Sen_E_785 | JH-RE-06 | -- | -- | | -- | Chemical compounds | MEFs | -- | Aging | Accelerate | | L | 33168727 |
| Sen_E_786 | Rosi | -- | -- | | -- | Chemical compounds | C57BL/6J(未做细胞实验） | -- | Aging | Prevent | | HL | 33219735 |
| Sen_E_787 | Quercetin | -- | -- | | -- | Chemical compounds | Dermal fibroblasts | Skin | Skin | Prevent | | HL | 33238152 |
| Sen_E_788 | KML001 | -- | -- | | -- | Chemical compounds | CD4+T | -- | Aging | Accelerate | | HL | 33268822 |
| Sen_E_789 | Methoxyeugenol | -- | -- | | Activation | Chemical compounds | Ishikawa cells | -- | Endometrial cancer | Accelerate | | L | 33271245 |
| Sen_E_790 | Alpha-lipoic acid | -- | -- | | -- | Chemical compounds | MDA-MB-231 | -- | Aging | Accelerate | | L | 33321563 |
| Sen_E_791 | ALA | HMGB1 | Downregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation | | -- | Chemical compounds | MDA-MB-231 cancer cells | -- | Breast cancer | Accelerate | | L | 33321563 |
| Sen_E_792 | SHEAD-CM,HGF,SCF | -- | -- | | Upregulation | Other | HBMSC | -- | Aging | Prevent | | L | 32736659 |
| Sen_E_793 | Size of MSCs | GROA//IL-8 | Downregulation | | -- | Other | UCB-MSC | -- | Aging | Prevent | | HL | 33401590 |
| Sen_E_794 | Apremilast | SIRT1 | Upregulation | | -- | Chemical compounds | ATDC5 | -- | Osteoarthritis | Prevent | | L | 33448323 |
| Sen_E_795 | t-BHP | HSP70 | Upregulation//Upregulation | | Activation//Activation | Chemical compounds | NPSCs | -- | Intervertebral disk | Accelerate | | L | 33511552 |
| Sen_E_796 | Daturataturin A | NF-κB | Downregulation | | Downregulation//Activation | Chemical compounds | HaCaT | -- | Aging | Accelerate | | L | 33560581 |
| Sen_E_797 | Silymarin | -- | -- | | -- | Chemical compounds | Chondrocyte | Cartilaginous tissues | Osteoarthritis | Prevent | | L | 33610183 |
| Sen_E_798 | Synthetic glucocorticoids | ANG//KI67//P16//P53//HMGB1 | Downregulation//Downregulation//Upregulation//Upregulation//Upregulation | | Downregulation | Chemical compounds | Osteoblasts,ostecytes,endothelial cells | -- | Aging | Accelerate | | L | 33758201 |
| Sen_E_799 | SRT1720 | SIRT1 | Upregulation | | Upregulation | Chemical compounds | Dermal fibroblasts | -- | Aging | Prevent | | L | 33965557 |
| Sen_E_800 | LEE011 | RB | Downregulation | | -- | Chemical compounds | BxPC-3,PANC-1,MiaPaCa-2 | -- | Pancreatic ductal adenocarcinoma | Accelerate | | L | 34001634 |
| Sen_E_801 | MEK162 | ERK | Downregulation | | -- | Chemical compounds | BxPC-3,PANC-1,MiaPaCa-2 | -- | Pancreatic ductal adenocarcinoma | Accelerate | | L | 34001634 |
| Sen_E_802 | Sargahydroquinoic acid | AKT//MTOR | Downregulation | | Downregulation | Chemical compounds | HUVEC | -- | Aging | Prevent | | L | 34022274 |
| Sen_E_803 | Apigenin | SIRT1//CD38 | Upregulation//Downregulation | | Downregulation | Chemical compounds | WI-38 | Lung | Aging | Prevent | | L | 34049472 |
| Sen_E_804 | CNF1 | -- | -- | | Upregulation//Upregulation//Upregulation | Chemical compounds | HCT116 | -- | Aging | Accelerate | | L | 30542142 |