| External factors: | Radiation |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Aging |
| Experiment: | CCK-8 assay//SA-β-gal activity assay//qRT-PCR//Cell proliferation assay |
| Description: | Radiation markedly inhibited cellular proliferation and increased the expression levels of the cellular senescence?associated genes Cdkn1a and Cdkn2c.Radiation exposure also significantly shortened the relative telomere length, impaired the relative telomerase activity and increased the percentage of SA?β?gal?positive cells. |
| Target gene: | MIR-34A |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | MIR-34A |
| Target gene experiment: | qRT-PCR |
| Target gene description: | miR?34a expression levels in HCMs were significantly increased following exposure to radiation. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: