Aging Overview

External factors

External factors: SN-38
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Colorectal cancer
Experimental category: L
Tissue type: --
Cell name: HCT116
PMID: 15374978
Experiment: SA-β-gal activity assay//Flow cytometry
Description: They remained metabolically Activate and showed a senescence-like phenotype—flattened morphology, increased granularity, and expression of senescence-associated β-galactosidase activity .Cells treated with 20 nm SN-38 for 24 hours underwent a G2 arrest (SN24h).


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.