Aging Overview

External factors

External factors: Teng-Long-Bu-Zhong-Tang
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Colorectal cancer
Experimental category: L
Tissue type: --
Cell name: CT26
PMID: 23758730
Experiment: SA-β-gal activity assay
Description: TLBZT treatment resulted in significant cell senescence in CT26 colon carcinoma compared with controls (P<0.01).


Regulatory relationship

Target gene: P16//P21//RB
R-EF-Target gene: Upregulation//Upregulation//Downregulation
Official symbol(s): P16//P21//RB
Target gene experiment: Western blot//Immunohistochemistry
Target gene description: We examined p16, p21 and RB phosphorylation in CT26 colon carcinoma after three weeks of TLBZT treatment by immunohistochemistry and western blot.TLBZT significantly upregulated p16 and p21 expression, and downregulated RB phosphorylation in CT26 colon carcinoma and compared with controls (P<0.01).

Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.