| External factors: | Teng-Long-Bu-Zhong-Tang |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Colorectal cancer |
| Experiment: | SA-β-gal activity assay |
| Description: | TLBZT treatment resulted in significant cell senescence in CT26 colon carcinoma compared with controls (P<0.01). |
| Target gene: | P16//P21//RB |
| R-EF-Target gene: | Upregulation//Upregulation//Downregulation |
| Official symbol(s): | P16//P21//RB |
| Target gene experiment: | Western blot//Immunohistochemistry |
| Target gene description: | We examined p16, p21 and RB phosphorylation in CT26 colon carcinoma after three weeks of TLBZT treatment by immunohistochemistry and western blot.TLBZT significantly upregulated p16 and p21 expression, and downregulated RB phosphorylation in CT26 colon carcinoma and compared with controls (P<0.01). |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: