Aging Overview

External factors

External factors: Pochoxime-derived inhibitor NW457
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Soft tissue sarcomas
Experimental category: HL
Tissue type: --
Cell name: HT-1080
PMID: 26044951
Experiment: SA-β-gal activity assay
Description: HT1080 cells displayed a dose-dependent accumulation of senescent cells, which was strongly enforced by pretreatment with 10 nM NW457.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.