| External factors: | Lidamycin |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Liver cancer |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis |
| Description: | We observed SA-β-gal expression, a senescence marker, at 72 h after lidamycin treatment. The treated cells showed phenotypic changes that resembled features of normal senescence, including enlarged and flattened morphology, increased granularity, vacuolization, and enhanced SA-β-gal- positive cells.Moreover, the induction of senescence-like phenotype in BEL-7402 cells was increased dose-dependently. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: