| External factors: | HRW |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | Western blot//SA-β-gal activity assay |
| Description: | The number of SA-β-gal-positive cells in the HRW mice were significantly reduced compared with NaIO3 mice. In addition, we further measured the expression of core proteins related to aging, such as, p53, p21 and p16, by western blot analysis. The levels of these proteins were conspicuously increased in NaIO3 mice compared with control mice. However, after HRW treatment, the expression of these proteins decreased greatly. |
| Target gene: | SIRT3 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | SIRT3 |
| Target gene experiment: | Western blot |
| Target gene description: | After HRW treatment, Sirt3 expression significantly increased compared with NaIO3 mice. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: