| External factors: | 20A |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Cervical cancer |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | 20A treatment resulted in a dose-dependent increase in the percentage of cells stained for β-galactosidase,suggesting that 20A causes senescence. 20A treatment elicited a significant time-dependent up-regulation of both p21 and p27 proteins in HeLa cells. |
| Regulatory pathway: | ATM |
| R-EF-Pathway: | -- |
| Official symbol(s): | ATM |
| Pathway experiment: | SA-β-gal activity assay//Western blot |
| Pathway description: | Loss of ATM significantly reduced senescence induced by 20A, irrespective of the presence or absence of p53 protein .The inhibition of ATM activation by KU55933 prevented 20A-induced accumulation of LC3-II. |
Annotation: