Aging Overview

External factors

External factors: Caloric restriction
Aging type: Prevent
Aging characteristic:
Category: Other
Phenotype: Aging
Experimental category: L
Tissue type: Bone
Cell name: White blood cell
PMID: 23349740
Experiment: Bone Density and Fat Content//The tightrope success test//Quantitative image analysis
Description: In line with this, both WT and TgTERT miceshowed BMD loss through life, as measured by DEXA, however,bone loss was significantly higher in mice under the control diet compared to calorie restricted mice.CR mice from both genotypes performed significantly better than mice under the control diet.The rate of telomere shortening was significantly slower in CR mice of both genotypes compared to the corresponding cohorts under the control diet.Similarly, WT and TgTERT mice under CR showed a lower rate of accumulation of short telomeres compared to the corresponding cohorts under the control diet.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.