Aging Overview

External factors

External factors: GAPDH
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Breast cancer
Experimental category: L
Tissue type: --
Cell name: MCF-7
PMID: 22847419
Experiment: SA-β-gal activity assay//Cell morphological analysis
Description: Cells expressing exogenous GAPDH exhibited an enlarged and flattened morphology characteristic of typical stress-induced premature senescence cells.Further staining of cells expressing elevated GAPDH for senescence-associated β-galactosidase (SA-β-Gal) activity confirmed the cellular senescence phenotype. Approximately 91% of cells with enlarged flattened morphology showed SA-β-Gal positivity vs.less than 10% in the controls.


Regulatory relationship

Target gene: TERC
R-EF-Target gene: --
Official symbol(s): TERC
Target gene experiment: --
Target gene description: --

Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.