External factors: | GAPDH |
Aging type: | Accelerate |
Aging characteristic: |
Category: | Chemical compounds |
Phenotype: | Breast cancer |
Experiment: | SA-β-gal activity assay//Cell morphological analysis |
Description: | Cells expressing exogenous GAPDH exhibited an enlarged and flattened morphology characteristic of typical stress-induced premature senescence cells.Further staining of cells expressing elevated GAPDH for senescence-associated β-galactosidase (SA-β-Gal) activity confirmed the cellular senescence phenotype. Approximately 91% of cells with enlarged flattened morphology showed SA-β-Gal positivity vs.less than 10% in the controls. |
Target gene: | TERC |
R-EF-Target gene: | -- |
Official symbol(s): | TERC |
Target gene experiment: | -- |
Target gene description: | -- |
Regulatory pathway: | -- |
R-EF-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation: