External factors: | Nicotinamide mononucleotide |
Aging type: | Prevent |
Aging characteristic: |
Category: | Chemical compounds |
Phenotype: | Aging |
Experiment: | SA-β-gal activity assay//qPCR//Western?blot |
Description: | The number of β-galacto-sidase positive cells was also decreased in cultures exposed to NMN .Additionally, the compound prevented FK866-induced RPE senescence as indicated by the suppression of p16INK4a and p21Waf/Cip1 expression and the reduction of SIRT1 expression . |
Target gene: | NAD+//SIRT1 |
R-EF-Target gene: | Upregulation//Upregulation |
Official symbol(s): | NAD//SIRT1 |
Target gene experiment: | qPCR//Western?blot |
Target gene description: | NMN dose-dependently enhanced NAD+ levels in cells exposed to FK866 .Importantly, NMN also prevented the FK866-induced decrease in SIRT1 expression. |
Regulatory pathway: | -- |
R-EF-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation: