Aging Overview

External factors

External factors: Nicotinamide mononucleotide
Aging type: Prevent
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: ARPE?19
PMID: 29905535
Experiment: SA-β-gal activity assay//qPCR//Western?blot
Description: The number of β-galacto-sidase positive cells was also decreased in cultures exposed to NMN .Additionally, the compound prevented FK866-induced RPE senescence as indicated by the suppression of p16INK4a and p21Waf/Cip1 expression and the reduction of SIRT1 expression .


Regulatory relationship

Target gene: NAD+//SIRT1
R-EF-Target gene: Upregulation//Upregulation
Official symbol(s): NAD//SIRT1
Target gene experiment: qPCR//Western?blot
Target gene description: NMN dose-dependently enhanced NAD+ levels in cells exposed to FK866 .Importantly, NMN also prevented the FK866-induced decrease in SIRT1 expression.

Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.