| External factors: | γ-irradiation |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | The senescence-associated β-galactosidase (SA-β-gal)staining showed that p73 knockdown significantly increased the proportion of positive cells (~89.1% in p73i-1 and 79.7% in p73i-2 transfected cells) at 5 dpi, compared to the irradiated controls (~41.2%). |
| Target gene: | TP73 |
| R-EF-Target gene: | Activation |
| Official symbol(s): | TP73 |
| Target gene experiment: | Flow cytometry |
| Target gene description: | The proportion of cells in the G2 phase increased significantly in irradiated p73-knockdown cells(30.2% in p73i-1 and 27.2% in p73i-2 transfected cells),compared to that in irradiated control cells (17.8%). |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: