| External factors: | RUT |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay//Telomerase activity assay |
| Description: | The percentage of positive SA-β-gal staining cells was increased, the telomerase activity was decreased and the expressions (both mRNA and protein) of both CGRP I and Klotho were down-regulated in Ang II-treated EPCs. Pretreatment with rutaecarpine reversed these effects in a dose-dependent manner. |
| Target gene: | KLOTHO |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | KLOTHO |
| Target gene experiment: | Western blot//PCR |
| Target gene description: | AngII was able to accelerate EPCs senescence as shown by the decrease in the expression of both Klotho mRNA and secreted Klotho protein,The effect was reversed by exogenous administration of RUT in a dose-dependent manner. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: