Aging Overview

External factors

External factors: Ionizing radiation
Aging type: Accelerate
Aging characteristic:
Category: Other
Phenotype: Aging
Experimental category: HL
Tissue type: --
Cell name: MCF-7
PMID: 26717900
Experiment: SA-β-gal activity assay//Western blot
Description: IR-exposed MCF7 cells exhibited specific characteristics of cellular senescence, such as enlarged, flattened morphological changes and positive senescence-associated β-galactosidase staining. These cells also showed pRb hypophosphorylation, p53 accumulation and p21 induction in western blot analyses.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.