Aging Overview

External factors

External factors: Etoposide
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: HL
Tissue type: --
Cell name: IMR-90
PMID: 28607003
Experiment: SA-β-gal activity assay//Western blot//Flow cytometry
Description: We confirmed the induction of the senescence phenotype in these cells by evaluation of cell cycle arrest, expression of senescence markers p16, p21, and p53 and senescence‐associated β‐galactosidase (SA‐β‐gal) staining. Treatment with etoposide induced cell cycle arrest in these cells.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.