| External factors: | 12-O-tetradecanoylphorbol-13-acetate |
| Aging type: | Prevent |
| Aging characteristic: |
| Category: | Chemical compounds |
| Phenotype: | Aging |
| Experiment: | RNA-seq//Cell morphological analysis |
| Description: | All data strongly supported the occurrence of cell cycle progression, along with the morphological and cytoskeletal changes in senescent cells linked with reduced focal adhesion to extracellular matrix. |
| Target gene: | PKCα//PERK1/2 |
| R-EF-Target gene: | Downregulation//-- |
| Official symbol(s): | PRKCA//MAPK1 |
| Target gene experiment: | Knockdown//Immunocytochemistry |
| Target gene description: | Indeed, the knockdown of PKCα expression significantly reduced pErk1/2 translocation after TPA treatment.The loss of PKCα expression was much faster after TPA treatment than after siPKCα transfection. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: