Aging Overview

External factors

External factors: Dehydroepiandrosterone
Aging type: Prevent
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: HAEC
PMID: 26051603
Experiment: SA-β-gal activity assay//Western blot
Description: When we pre-treated with 50 nmol/L of DHEA for 1h prior to LA treatment,the number of SA-β-Gal-positive cells significantly decreased compared to the cells treated with LA alone.However,pre-treatment with DHEA substantially increased the protein level of ppRB(an indicator of senescence).


Regulatory relationship

Regulatory pathway: JNK
R-EF-Pathway: Activation
Official symbol(s): MAPK8
Pathway experiment: SA-β-gal activity assay//Western blot
Pathway description: After HAECs were pre-treated with the JNK inhibitor, the inhibitory effect disappeared. Similarly, the increased expression of ppRB by DHEA treatment was also abolished after JNK inhibition.


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



Pathway view