AgingReG
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Aging Overview

External factors

External factors: Dehydroepiandrosterone
Aging type: Prevent
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: HAEC
PMID: 26051603
Experiment: SA-β-gal activity assay//Western blot
Description: When we pre-treated with 50 nmol/L of DHEA for 1h prior to LA treatment,the number of SA-β-Gal-positive cells significantly decreased compared to the cells treated with LA alone.However,pre-treatment with DHEA substantially increased the protein level of ppRB(an indicator of senescence).

Regulatory relationship

Regulatory pathway: JNK
R-EF-Pathway: Activation
Official symbol(s): MAPK8
Pathway experiment: SA-β-gal activity assay//Western blot
Pathway description: After HAECs were pre-treated with the JNK inhibitor, the inhibitory effect disappeared. Similarly, the increased expression of ppRB by DHEA treatment was also abolished after JNK inhibition.

Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.


Pathway view

Activation of the AP-1 family of transcription factorsAKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) ) Alzheimer disease-amyloid secretase pathwayAngiogenesisAngiopoietin receptor Tie2-mediated signalingApoptosis signaling pathwayATF-2 transcription factor networkB cell activationBCRBCR signaling pathwayCD40/CD40L signalingCDC42 signaling eventsCeramide signaling pathwayCytokine gene transcriptionDownstream signaling in naïve CD8+ T cellsDrosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling ) DSCAM interactionsEGFR1EndothelinsEphrin B reverse signalingEPO signaling pathwayErbB1 downstream signalingErbB2/ErbB3 signaling eventsERK cascade ( CD4 T cell receptor signaling (ERK cascade) ) FAS (CD95) signaling pathwayFas signaling pathway ( Fas signaling pathway ) FAS signaling pathwayFc-epsilon receptor I signaling in mast cellsFc Epsilon Receptor I Signaling in Mast CellsFCERI mediated MAPK activationFoxO family signalingGlucocorticoid receptor regulatory networkGlypican 3 networkHIV-1 Nef: Negative effector of Fas and TNF-alphaIL1-mediated signaling eventsIL1IL12 signaling mediated by STAT4IL2-mediated signaling eventsIL2IL3IL4IL6Integrin signaling pathway ( Integrin signaling pathway ) Integrin signalling pathwayInterferon-gamma signaling pathwayIntracellular Signalling Through Adenosine Receptor A2a and AdenosineIntracellular Signalling Through Adenosine Receptor A2b and AdenosineJNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1JNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) JNK cascade ( CD4 T cell receptor signaling ) JNK cascade ( TGF-beta signaling(through TAK1) ) JNK cascade ( Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade) ) JNK signaling in the CD4+ TCR pathwayKitReceptorLeptinN-cadherin signaling eventsNegative regulation of (nuclear import of R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) Nephrin/Neph1 signaling in the kidney podocyteNoncanonical Wnt signaling pathwayNRAGE signals death through JNKNRIF signals cell death from the nucleusOsteopontin-mediated eventsOxidative Stress Induced SenescenceOxidative stress responsep53 pathwayp75(NTR)-mediated signalingParkinson diseasePDGF signaling pathwayPDGFR-beta signaling pathwayPositive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) ProlactinRAC1 signaling pathwayRANKLRapid glucocorticoid signalingRas PathwayRecruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksReelin signaling pathwayRegulation of Androgen receptor activityRetinoic acid receptors-mediated signalingRhoA signaling pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytesS1P2 pathwaySignaling events mediated by focal adhesion kinaseSignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)Signaling events mediated by Stem cell factor receptor (c-Kit)Signaling events regulated by Ret tyrosine kinaseSyndecan-2-mediated signaling eventsT cell activationTCRTGF-beta signaling pathwayTGF_beta_ReceptorTNFalphaToll receptor signaling pathwayTRAIL signaling pathwayTSLPTWEAKVEGF signaling pathway ( VEGF signaling pathway ) WntJNK cascade ( IL-1 signaling pathway (through JNK cascade) ) JNK cascade ( TNFR1 signaling pathway ) JNK cascade ( Toll-like receptor signaling pathway (through JNK cascade) ) p38 cascade ( IL-1 signaling pathway (through p38 cascade) ) MAPK signaling pathwayErbB signaling pathwayProtein processing in endoplasmic reticulumWnt signaling pathwayFocal adhesionToll-like receptor signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathwayFc epsilon RI signaling pathwayNeurotrophin signaling pathwayInsulin signaling pathwayGnRH signaling pathwayProgesterone-mediated oocyte maturationAdipocytokine signaling pathwayType II diabetes mellitusEpithelial cell signaling in Helicobacter pylori infectionShigellosisChagas diseaseToxoplasmosisHepatitis CPathways in cancerColorectal cancerPancreatic cancerHs_ErbB_Signaling_Pathway_WP673_91869Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017Hs_Association_Between_Physico-Chemical_Features_and_Toxicity_Associated_Pathways_WP3680_90113Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640Hs_Wnt_Signaling_Pathway_Netpath_WP363_78571Hs_Apoptosis_Modulation_and_Signaling_WP1772_91293Hs_PDGF_Pathway_WP2526_82681Hs_Fas_Ligand_(FasL)_pathway_and_Stress_induction_of_Heat_Shock_Proteins_(HSP)_regulation_WP314_87381Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668Hs_Rac1-Pak1-p38-MMP-2_pathway_WP3303_87628Hs_Transcriptional_activation_by_NRF2_WP3_79527Hs_MicroRNAs_in_cardiomyocyte_hypertrophy_WP1544_89794Hs_TNF_alpha_Signaling_Pathway_WP231_89895Hs_Type_II_diabetes_mellitus_WP1584_81779Hs_G1_to_S_cell_cycle_control_WP45_80001Hs_Osteoclast_Signaling_WP12_88602Hs_TGF-beta_Signaling_Pathway_WP366_90028Hs_EGF-EGFR_Signaling_Pathway_WP437_79266Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937Hs_IL-1_signaling_pathway_WP195_89932Hs_IL-3_Signaling_Pathway_WP286_78583Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900
Expression of gene(s)
Cell line (ENCODE) Primary cell (ENCODE) Normal tissue (GTEx) Cell line (CCLE)