| External factors: | UVB |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | Aging |
| Experiment: | SA-β-gal activity assay |
| Description: | Keratinocytes exposed to increasing doses of UVB radiation exhibited significant increases (of 6- to 8-fold) in SA β-gal activity, a biomarker for cellular senescence, relative to the unexposed control cells. Similar results were obtained in immunofluorescent histochemical analyses using p53, p21, p16 or PML, which are also known biomarkers of cellular senescence. |
| Regulatory pathway: | -- |
| R-EF-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation: