Aging Overview

External factors

External factors: Salvia haenkei
Aging type: Prevent
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: Fibroblast
PMID: 27922821
Experiment: SA-β-gal activity assay//Cell viability assay
Description: While untreated cells stopped growing at passage 30,cells treated with SH continued to proliferate. Moreover,senescence in treated cells was significantly decreased when compared to control as assessed by the SA-β-Gal staining.The reduction in the percentage of SA-β-Gal staining in these cells was comparable to the one observed in Pten null MEFs showing a correspondence between these two models. Importantly, treatment of cells with SH for a period of three months was not associated to increased cell death, as demonstrated by the cell viability assay.


Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.