| External factors: | HIV |
| Aging type: | Accelerate |
| Aging characteristic: |
| Category: | Other |
| Phenotype: | AIDS |
| Experiment: | Flow cytometry analysis |
| Description: | HIV infection increased ?the number of early apoptotic and late apoptotic cells thereafter (days 4 to 6). SupT1 cells with HIV infection cultured for 3 to 6?days displayed significantly shortened telomeres compared to uninfected cells, especially at day 6. |
| Target gene: | P24 |
| R-EF-Target gene: | Upregulation |
| Official symbol(s): | P24 |
| Target gene experiment: | Western blot |
| Target gene description: | Western blot ?analysis revealed HIV dose-dependent changes in p24 expression in SupT1 cells. |
| Regulatory pathway: | PI3K-ATM |
| R-EF-Pathway: | Downregulation |
| Pathway experiment: | Western blot |
| Pathway description: | Intriguingly, compared to the uninfected controls (lane ?1), HIV-infected cells (lane 2) exhibited a slight decrease in total ATM but an increase in ?pATM, likely reflecting HIV-induced DDR. In parallel, levels of total CHK2 and AKT ?proteins were decreased, but levels of pCHK2 and pAKT were significantly increased by ?HIV infection, along with elevation of the DDR-mediated apoptotic markers H2AX and ?PARP1. |
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